Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The SI values calculated for the substance concentrations 1, 2.5 and 5% were 11.4, 18.5 and 24.7 respectively. These results show that the test substance elicits an SI ≥ 3. The EC3 value (the estimated test substance concentration that will give a SI =3) was established to be between 0 and 1%. Based on these results: - according to the recommendations made in the test guidelines, Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate would be regarded as skin sensitizer. - according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2011), Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate should be classified as strong skin sensitizer (Category 1, Sub-category 1A). - according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate should be classified as skin sensitizer (Category 1) and labeled as H317: May cause an allergic skin reaction.
Migrated from Short description of key information:
In an OECD TG 429 study, this substance would be regarded as skin sensitizer.
Justification for classification or non-classification
Please see above "Discussion".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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