Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015.3.27-2015.5.13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.24
Temp.:
20 °C
Remarks on result:
other: pH data was not available
Details on results:
Recoveries of Red 620 in octanol phase and water phase were 85.3±3.1%, 83.3±1.3%, respectively and the Relative Standard Deviation (RSD) was less than 20% (Table 1, 2).
LogPow values of Red 620 from the all three runs with the different solvents ratios were 1.28±0.01 (2 mL, test 1), 1.15±0.04 (4 mL, test 2), 1.29±0.00 (1 mL, test 3). The average value of LogPow is 1.24 ± 0.08 (Table 3, Fig 1).

Applicant's summary and conclusion

Conclusions:
The average logPow value from the all three runs with the different solvents ratios was 1.24± 0.08. The variation of partition coefficient calculated with different volume ratio was within ±0.3 logPow. This result was acceptable range specified by the National Institute of Environmental Research, Korea and OECD test guidelines.