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Diss Factsheets
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EC number: 676-237-4 | CAS number: 71294-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU/OECD-guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 7-fluoro-2,3-dihydro-1H-indol-2-one
- EC Number:
- 676-237-4
- Cas Number:
- 71294-03-6
- Molecular formula:
- C8H6FNO
- IUPAC Name:
- 7-fluoro-2,3-dihydro-1H-indol-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Doses:
- 50, 300, 2000 mg/kg bw
- No. of animals per sex per dose:
- 15 animals, 3 animals/group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One of six females dosed at 50 mg/kg bw were found dead on Day 2.
No mortality was observed in six females dosed at 300 mg/kg bw.
Two of three females dosed at 2000 mg/kg bw were found dead on Day 0 or Day 1. - Clinical signs:
- other: 50 mg/kg body weight (six animals): Treatment with test item at the dose level of 50 mg/kg bw caused decreased activity (2/6), hunched back (6/6), piloerection (1/6), incoordination (1/6) and dyspnoea (1/6). Surviving animals were symptom-free from Day 2.
- Gross pathology:
- Found dead
Three females were found dead on Day 0, 1 or 2.
Yellow liquid material found in the digestive contents of the stomach and/or
duodenum and jejunum in 2 females dosed at 2000 mg/kg bw was considered to be
test item-related.
In the female dosed at 50 mg/kg bw, dilated thoracic esophagus with creamy brown
material mixed with diet was observed and considered as regurgitated test item due to
possible gastro-oesophageal reflux.
In addition, dark/red discoloration of the non-collapsed lungs or red dry material at the
perioral/perinasal fur, were regarded as agonal or post mortem. - Other findings:
- TERMINAL (DAY 14)
There was no evidence of the macroscopic observations in animals dosed at 300 mg/kg bw and terminated on Day 14.
No test item-related changes were seen in surviving animals dosed at 50 or 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute oral LD50 value of the test item was found to be between 300 and 2000 mg/kg bw in female CRL:(WI) rats.
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