Registration Dossier
Registration Dossier
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EC number: 943-794-2 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 129
- Version / remarks:
- The study design was based on the OECD Guidance document on using cytotoxicity tests to estimate
starting doses for acute oral systemic toxicity tests. No. 129, 20th July 2010. - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- EC Number:
- 242-640-5
- EC Name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- Cas Number:
- 18871-14-2
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-O-acetyl-1,5-anhydro-2,4-dideoxy-2-pentylpentitol
- Reference substance name:
- Nonane-1,3-diyl diacetate
- EC Number:
- 264-060-1
- EC Name:
- Nonane-1,3-diyl diacetate
- Cas Number:
- 63270-14-4
- Molecular formula:
- C13H24O4
- IUPAC Name:
- nonane-1,3-diyl diacetate
- Reference substance name:
- 1-(tetrahydrofuran-3-yl)hexyl acetate
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 1-(tetrahydrofuran-3-yl)hexyl acetate
- Reference substance name:
- rel-(3R,4R)-3-pentyltetrahydro-2H-pyran-4-ol
- Cas Number:
- 24646-98-8
- Molecular formula:
- C10H20O2
- IUPAC Name:
- rel-(3R,4R)-3-pentyltetrahydro-2H-pyran-4-ol
- Reference substance name:
- 3-hydroxynonyl acetate
- Cas Number:
- 902270-36-4
- Molecular formula:
- C11H22O3
- IUPAC Name:
- 3-hydroxynonyl acetate
- Test material form:
- liquid
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
- Specific details on test material used for the study:
- CAS number in the study report (18871-14-2) indicates the main component in Jasmonyl. However recent analytical data shows that Jasmonyl is a reaction mass of nonane-1,3-diyl diacetate and tetrahydro-3-pentyl-2H-pyran-4-yl acetate. The test substance used in this study was Reaction mass of nonane-1,3-diyl diacetate and tetrahydro-3-pentyl-2H-pyran-4-yl acetate.
Test animals
- Species:
- other: Mouse fibroblast cell line, Balb/c 3T3, clone A31, from the American Type Culture Collection (ATCC cell line No. CCL-163).
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 586 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the experimental conditions of this study, the test item, Jasmonyl, is not considered as cytotoxic in this in vitro test system up to the highest tested concentration of 100 μg/mL. Taking into account this highest tested concentration, the test item LD50 is estimated to be greater than 586 mg/kg.
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