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EC number: 807-040-5 | CAS number: 4538-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1,5-Diisocyanatopentane
- EC Number:
- 807-040-5
- Cas Number:
- 4538-42-5
- Molecular formula:
- C7H10N2O2
- IUPAC Name:
- 1,5-Diisocyanatopentane
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Orient Bio Co., Ltd. 8, Hwaaksan-ro 124beon-gil, Buk-myeon, Gapyeong-gun, Gyeonggi-do, Korea
- Age at study initiation: approx. 9 weeks
- Weight at study initiation: 200-211 g
- Housing: less than 3 animals per cage
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: at least 6 days Quarantine and acclimatization periods
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C 20.6-23.6
- Humidity (%): 55 ± 10 °C 49.8-62.0
- Photoperiod (hrs dark / hrs light): 12h rhythm
IN-LIFE DATES: From: 22 January 2019 To: 28 February 2019
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Test substance was formulated with vehicle at 30 mg/mL (1st step), 5 mg/mL (2nd, 3rd step) concentration. The administration volume was 10 mL/kg b.w. The formulated test substance was not analysed for concentration, stability and homogeneity.
- Doses:
- 300 mg/kg and 50 mg/kg
- No. of animals per sex per dose:
- 3 (300 mg/kg) and 6 (2x 3 at 50 mg/kg)
- Control animals:
- no
- Details on study design:
- Clinical signs were carefully observed for 0.5, 1, 2, 3 and 4 hours after administration and then once each day for 14 days.
Body weights were measured at animal receipt day, animal allocation day, just before treatment and on day 1, 3, 7 and 14 after the administration, found death animal.
At the end of observation period and death animal, external observations were conducted and sacrificed by blood letting under anesthesia for all survived animals.Then the organs were examine for gross lesions. - Statistics:
- No statistical analysis could be performed (the method used is not intended to allow a calculation of a precise LD50 value).
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The test substance-related death of 2 animals was observed at the dose of 300 mg/kg bw on day 1 and day 2, respectively.
- Clinical signs:
- In clinical signs, diarrhea, staining around mouth, soiled perineal region were observed in the dose of 300 mg/kg body weight (1st step).
And, soft stool were observed in the dose of 50 mg/kg body weight (2nd, 3rd step).
Soiled perineal region were observed in the dose of 50 mg/kg body weight (3rd step). - Body weight:
- In body weight for animal except dead animals, one animal showed body weight decrease in the dose of 300 mg/kg bw (1st step) on 1 day as compared with administration day. One animal showed body weight decrease in the dose of 50 mg/kg bw (2nd step) on 3 days as compared with 1 day. Three animals showed body weight decrease in the dose of 50 mg/kg bw (2nd, 3rd step) on 14 days as compared with 7 days after administration.
- Gross pathology:
- In the necropsy finding of dead animals, external findings of soiled perineal region were observed and internal findings of retention of test substance in the stomach and enlarged adrenal gland were observed in the dose of 300 mg/kg body weight (1st step). In the necropsy of survived animals, there were no abnormal findings caused by administration of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Executive summary:
The acute oral LD50 in rats is determined to >50 mg/kg bw and <300 mg/kg bw based on the results of a study performed according to OECD TG 423. The test dose of 300 mg/kg resulted in death (2 animals), clinical signs such as diarrhea, soft stool, soiled perineal region and staining around mouth, temporary body weight decrease in one animal and necropsy findings such as retention of test substance in the stomach and enlarged adrenal gland.
The test dose of 50 mg/kg resulted in clinical signs such as soft stool and soiled perineal region and temporary body weight decrease.
In the necropsy of survived animals, there were no abnormal findings caused by administration of the test substance.
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