Registration Dossier
Registration Dossier
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EC number: 943-932-1 | CAS number: 26834-28-6
Endpoint summary
Administrative data
Description of key information
Studies on skin and eye irritation are available on LiDNNSA, DNNSA and BaDNNSA. These studies are indicative of moderate to severe irritation to the skin and eyes. Based on the results of the studies on DNNSA (severe eye irritant), BaDNNSA (skin irritant) and the mono-salt LiDNNSA (skin and eye irritant), it was concluded in a worst case approach that a read-across is possible and that NaDNNSA is expected to be irritating to the skin and eyes. This outcome is confirmed by skin and eye irritation studies on NaDNNSA, where a formulation containing a corrosive substance induced skin and eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The available studies contain sufficient information to be used for classification and labelling.
Justification for selection of skin irritation / corrosion endpoint:
Studies on analogues were conducted prior to GLP regulations but used methods generally consistent with accepted procedures. All studies are of equal quality and can be used in a weight of evidence. The results of these studies are comparable and show irritation to the skin
Justification for selection of eye irritation endpoint:
Studies on analogues were conducted prior to GLP regulations but used methods generally consistent with accepted procedures. All studies are of equal quality and can be used in a weight of evidence. The results of these studies are comparable and show irritation to the eyes
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the outcome of the available tests, the test substance needs to classified as skin irritant (CLP category 2, H315: Causes skin
irritation) and severe eye irritant (CLP category 2, H319: Causes serious eye irritation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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