Registration Dossier
Registration Dossier
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EC number: 939-053-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Data from in vitro Membrane Barrier Test Method for Skin Corrosion according to OECD guideline 435 are available for Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An in vitro Membrane Barrier Test Method for Skin Corrosion was conducted according to OECD guideline 435 with Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid, aqueous solution using the Corrositex®- Test.
Four vials with a synthetic biobarrier and a CDS (= Chemical Detection System) were treated with 500 µL of the liquid test item were applied to each biobarrier and observed for possible penetration.
10% Citric acid was used as negative control, NaOH was used as positive control.
The negative control showed no break-through and therefore no corrosive effects, the measured time of the positive control was 12.83 min, thus ensuring the validity of the test system.
The test item Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid, aqueous solution showed corrosive effects in average after 8.98 minutes.
In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid, aqueous solution possesses skin corrosion potential and is classified as a corrosive substance belonging to UN Packing Group II, GHS classification: skin corrosion category 1B.
Therefore, Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid, aqueous solution is considered as corrosive in the Corrositex®- Test.
Justification for selection of skin irritation / corrosion endpoint:
Reliable data are available from an in vitro Membrane Barrier Test Method for Skin Corrosion according to OECD guideline 435.
The key study is GLP-compliant and of high quality (Klimisch 1).
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
According to the CLP Regulation (EU GHS Regulation (EC) No 1272/2008) Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid has to be classified with skin corrosion category 1B according to an OECD 435 (in vitro Membrane Barrier Test Method for Skin Corrosion) study.
Labelling with H314 “Causes severe skin burns and eye damage“ is required accordingly.
The method is approved by international regulatory agencies as a replacement for the identification of corrosives in the in vivo Rabbit skin assay (OECD 404). Positive results do not generally require further testing and can be used for classification.
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