Registration Dossier
Registration Dossier
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EC number: 266-026-1 | CAS number: 65996-91-0 The distillate from coal tar having an approximate distillation range of 220°C to 450°C (428°F to 842°F). Composed primarily of three to four membered condensed ring aromatic hydrocarbons and other hydrocarbons.
Endpoint summary
Administrative data
Description of key information
No acute toxicity was observed after single oral, dermal and inhalational administration of the supporting substances wash oil and creosote to rats thus characterising Distillates (coal tar), upper by analogy as not being acutely toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 5 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
No data on acute toxicity is available for the substance distillates (coal tar), upper itself. Data obtained originate from the closely related tar oils creosote and wash oil. Due to the similar production process (fractionated distillation of coal tar using overlapping conditions), composition of both substances correspond to each other. Major components are mid-range PAH for both substances (2, 3- and 4-ring PAH).
The acute toxicity of both materials can be considered to be similar. Therefore, creosote/wash oil is used as supporting substance in characterising the acute toxicity of distillates (coal tar), upper
Acute toxicity of creosote is demonstrated to be low: LD50(oral, rat) ca. 4000 mg/kg bw, LD50(dermal, rat) > 2000 mg/kg bw, discrimination dose (inhalation, rat) 5000 mg/m³. The wash oil study also showed an acute oral toxicity of > 2000 mg/kg bw.
Based on data of the supporting substances creosote and wash oil, distillates (coal tar), upper is characterised to show no or only weak acute toxicity not relevant for classification.
Justification for classification or non-classification
Based on experimental evidence, no classification required (LD/LC 50 values clearly above classification criteria of Regulation (EC) No 1272/2008).
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