Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from study report by Commission of the European Communities

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity study of test chemical was performed in mice.
Author:
COMMISSION OF THE EUROPEAN COMMUNITIES
Year:
1988
Bibliographic source:
REPORTS of the Scientific Committee on Cosmetology(seventh series)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: refer below principle
Principles of method if other than guideline:
Acute oral toxicity study of 1- (2, 4-dimethylphenylazo)-2-naphthol in mice.
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula: C18H16N2O
- Molecular weight : 276.337 g/mol
- Smiles notation : c12c(\N=N/c3c(cc(C)cc3)C)c(ccc1cccc2)O
- InChl : 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3
- Structural formula attached as image file : No data available
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula (if other than submission substance): C18H16N2O
- Molecular weight (if other than submission substance): 276.337 g/mol
- Smiles notation (if other than submission substance): c12c(\N=N/c3c(cc(C)cc3)C)c(ccc1cccc2)O
- InChl (if other than submission substance): 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3
- Structural formula attached as image file (if other than submission substance): No data available
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
20 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % Mortality was observed in treated mice
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 20,000 mg/kg bw. When mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally.
Executive summary:

In acute oral toxicity study, mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally. 50 % Mortality was observed in treated mice at 20,000 mg/kg bw. Therefore, LD50 was considered to be 20,000 mg/kg bw. When mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally.