Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-490-4 | CAS number: 3118-97-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from study report by Commission of the European Communities
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical was performed in mice.
- Author:
- COMMISSION OF THE EUROPEAN COMMUNITIES
- Year:
- 1 988
- Bibliographic source:
- REPORTS of the Scientific Committee on Cosmetology(seventh series)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Acute oral toxicity study of 1- (2, 4-dimethylphenylazo)-2-naphthol in mice.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 1- (2, 4-dimethylphenylazo)-2-naphthol
- IUPAC Name:
- 1- (2, 4-dimethylphenylazo)-2-naphthol
- Reference substance name:
- 1-(2,4-dimethylphenylazo)-2-naphthol
- EC Number:
- 221-490-4
- EC Name:
- 1-(2,4-dimethylphenylazo)-2-naphthol
- Cas Number:
- 3118-97-6
- Molecular formula:
- C18H16N2O
- IUPAC Name:
- 1-(2,4-dimethylphenylazo)-2-naphthol
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula: C18H16N2O
- Molecular weight : 276.337 g/mol
- Smiles notation : c12c(\N=N/c3c(cc(C)cc3)C)c(ccc1cccc2)O
- InChl : 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3
- Structural formula attached as image file : No data available
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula (if other than submission substance): C18H16N2O
- Molecular weight (if other than submission substance): 276.337 g/mol
- Smiles notation (if other than submission substance): c12c(\N=N/c3c(cc(C)cc3)C)c(ccc1cccc2)O
- InChl (if other than submission substance): 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3
- Structural formula attached as image file (if other than submission substance): No data available
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 20 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % Mortality was observed in treated mice
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 20,000 mg/kg bw. When mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally.
- Executive summary:
In acute oral toxicity study, mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally. 50 % Mortality was observed in treated mice at 20,000 mg/kg bw. Therefore, LD50 was considered to be 20,000 mg/kg bw. When mice were treated with 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
