Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-441-2 | CAS number: 615-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Appearance
In an experiment conducted by SSS(Europe)AB, on the basis of visual perceptual/Olfactory property, the chemical 2-chloro-p-phenylenediamine was found to be a steel grey coloured powder in appearance.
Melting point
The melting point of 2-chloro-p-phenylenediamine was determined according to Differential scanning calorimetry (DSC) method using Mettler Toledo, DSC 823e apparatus. The melting point of 2-chloro-p-phenylenediamine was found to be 63°C.
Boiling point
The Adapted Stein and Brown method was used to estimate the boiling point of 2-chloro-p-phenylenediamine using MPBPVP v1.43 Program of EPI SUITE. The boiling point of 2-chloro-p-phenylenediamine was estimated to be 280.29 deg C.
Density
The density of 2-chloro-p-phenylenediamine (CAS No. 615-66-7 ) was determined according to DIN 51913 method using gas pycnometer. The density of test item 2-chloro-p-phenylenediamine was found to be 1.4201 g/cm3 at 23°C.
Particle Size Distribution
The particle size distribution of 2-chlorobenzene-1,4-diamine was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 53 micron.
Vapor Pressure
The Modified Grain method was used to estimate the vapour pressure of 2-chloro-p-phenylenediamine using MPBPVP v1.43 Program of EPI SUITE. The vapour pressure of 2-chloro-p-phenylenediamine was estimated to be 0.274 Pa (0.00206 mm Hg) at 25 deg C.
Partition Coefficient
The partition coefficient (log Pow) of the test substance 2-chloro-p-phenylenediamine was determined according to the OECD Guideline for the testing of chemicals 107.
Result:
Determination No. |
Ratio n-octanol : water |
Log Pow |
A1 |
2:1 |
0.43 |
A2 |
2:1 |
0.45 |
B1 |
1:1 |
0.44 |
B2 |
1:1 |
0.44 |
C1 |
1:2 |
0.45 |
C2 |
1:2 |
0.44 |
Mean |
--- |
0.44 |
The octanol-water partition coefficient (log Pow) of the test substance 2-chloro-p-phenylenediamine was determined to be 0.44 at 20 -25 degC. This value indicates that the substance 2-chloro-p-phenylenediamine is hydrophilic in nature which is also supported by its solubility in water.
Water Solubility
The water solubiliity of 2-chloro-p-phenylenediamine was estimated by using WSKOW v1.42 method of EPI Suite.The water solubility of 2-chloro-p- phenylenediamine was estimated to be 49610 mg/L at 25 degC, indicating that the substance is very soluble in water.
Surface tension
In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The chemical 2-chloro-p-phenylenediamine is an aniline derivative used as a hair and fur dye, photographic developer, in photochemical measurements, chemical intermediate in the manufacturing of dyes, antioxidants and rubber accelerators. For these uses, surface activity is not a desired property and hence this end point was considered for waiver.
Flash point
The flash point of 2-chloro-p-phenylenediamine was predicted using the ACD/Labs Percepta Platform - PhysChem Module.The flash point of 2-chloro-p- phenylenediamine was estimated to be 127.9±21.8°C.
Autoflammability
The study does not need to be conducted because the substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) has melting point 63°C which was less than 160 degree C. Therefore this end point considered for waiver.
Flammability
The study does not need to be conducted because the substance is a solid, as the 2-chloro-p-phenylenediamine has NFPA rating 0 and the flash point is 127.9 degree C which is very high. As per the CLP regulation the chemical which has flash point >than 60 degree C was considered to be non-flammable. Based on this 2-chloro-p-phenylenediamine was considered to be non-flammable supported by low NFPA rating.
Explosiveness
In accordance with column 2 of Annex VII of the REACH regulation, the study is scientifically unjustified since there are no chemical groups associated with explosive properties present in the molecule of 2-chloro-p-phenylenediamine. Thus, the chemical 2-chloro-p-phenylenediamine is not likely to be explosive and is considered to be "Non explosive" for the purpose of chemical safety assessment.
Oxidising properties
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied.
Viscosity
This end point was considered for waiver since viscosity is an inherent property of a liquid that offers resistance to its flow and 2-chloro-p-phenylenediamine is a solid substance and hence this testing was considered scientifically unjustified for 2-chloro-p-phenylenediamine.
Additional information
Appearance
In an experiment conducted by SSS(Europe)AB, on the basis of visual perceptual/Olfactory property, the chemical 2-chloro-p-phenylenediamine was found to be a steel grey coloured powder in appearance.
The supporting study from reliable handbook and database, also indicates that 2-chloro-p-phenylenediamine to be a needle shape organic solid substance.
Melting point
The melting point of 2-chloro-p-phenylenediamine was determined according to Differential scanning calorimetry (DSC) method using Mettler Toledo, DSC 823e apparatus. The melting point of 2-chloro-p-phenylenediamine was found to be 63°C.
Based on the data from other supporting study from various reliable sources such as handbooks (Sax's Handbook of Dangerous Industrial Materials, 2007); the melting point of 2-chloro-p-phenylenediamine was reported as 64°C which is in the range of key study value.
As the data from experimental study has K1 reliability and the test was performed in accordance with procedure AA 1020 - 1129 which has the value of melting point temperature as 63 degree C, thus considered as key study for the chemical safety assessment.
Boiling point
The Adapted Stein and Brown method was used to estimate the boiling point of 2-chloro-p-phenylenediamine using MPBPVP v1.43 Program of EPI SUITE. The boiling point of 2-chloro-p-phenylenediamine was estimated to be 280.29 deg C.
Density
The density of 2-chloro-p-phenylenediamine (CAS No. 615-66-7 ) was determined according to DIN 51913 method using gas pycnometer. The density of test item 2-chloro-p-phenylenediamine was found to be 1.4201 g/cm3 at 23°C.
Moreover, the density of 2-chloro-p-phenylenediamine was predicted using the ACD/Labs Percepta Platform - PhysChem Module. The density was estimated to be 1.3±0.1 g/cm³ at 25 degC.
As the data from experimental study has K1 reliability and the test was performed using national standard method which has the value of density as 1.4201 g/cm3 at 23°C., thus considered as key study for the chemical safety assessment.
Particle Size Distribution
The particle size distribution of 2-chlorobenzene-1,4-diamine was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 53 micron.
Vapor Pressure
The Modified Grain method was used to estimate the vapour pressure of 2-chloro-p-phenylenediamine using MPBPVP v1.43 Program of EPI SUITE. The vapour pressure of 2-chloro-p-phenylenediamine was estimated to be 0.274 Pa (0.00206 mm Hg) at 25 deg C.
Partition Coefficient
The partition coefficient (log Pow) of the test substance 2-chloro-p-phenylenediamine was determined according to the OECD Guideline for the testing of chemicals 107. The octanol-water partition coefficient (log Pow) of the test substance 2-chloro-p-phenylenediamine was determined to be 0.44 at 20-25 degC.
Based on the supporting study from predictive models, the octanol-water partition coefficient (log Pow) of 2-chloro-p-phenylenediamine was estimated by KOWWIN Program (v1.68) of EPI suite. The octanol-water partition coefficient (log Kow) of 2-chloro-p-phenylenediamine was estimated to be 0.25 at 25 degC.
Based on the experimental and estimated values, the substance 2-chloro-p-phenylenediamine can be considered as hydrophilic in nature which is also supported by its solubility in water.
As the data from the experimental study has K1 reliability and the test was performed using OECD guidelines which has the value of Log Pow as 0.44 at 20-25°C, indicating that 2-chloro-p-phenylenediamine is hydrophilic in nature., thus considered as key study for the chemical safety assessment.
Water Solubility
The water solubiliity of 2-chloro-p-phenylenediamine was estimated by using WSKOW v1.42 method of EPI Suite.The water solubility of 2-chloro-p-phenylenediamine was estimated to be 49610 mg/L at 25 degC, indicating that the substance is very soluble in water.
Surface tension
In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The chemical 2-chloro-p-phenylenediamine is an aniline derivative used as a hair and fur dye, photographic developer, in photochemical measurements, chemical intermediate in the manufacturing of dyes, antioxidants and rubber accelerators. For these uses, surface activity is not a desired property and hence this end point was considered for waiver.
Flash point
The flash point of 2-chloro-p-phenylenediamine was predicted using the ACD/Labs Percepta Platform - PhysChem Module. The flash point of 2-chloro-p-phenylenediamine was estimated to be 127.9±21.8°C. Based on the criteria mentioned in CLP regulation, the chemical has a flash point > 60 degree C and hence the substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) was considered to be non-flammable.
Autoflammability
The study does not need to be conducted because the substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) has melting point 63°C which was less than 160 degree C. Therefore this end point considered for waiver.
Flammability
The study does not need to be conducted because the substance is a solid, as the 2-chloro-p-phenylenediamine has NFPA rating 0 and the flash point is 127.9 degree C which is very high. As per the CLP regulation the chemical which has flash point >than 60 degree C was considered to be non-flammable. Based on this 2-chloro-p-phenylenediamine was considered to be non-flammable supported by low NFPA rating.
Explosiveness
In accordance with column 2 of Annex VII of the REACH regulation, the study is scientifically unjustified since there are no chemical groups associated with explosive properties present in the molecule of 2-chloro-p-phenylenediamine. Thus, the chemical 2-chloro-p-phenylenediamine is not likely to be explosive and is considered to be "Non explosive" for the purpose of chemical safety assessment.
Oxidising properties
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied.
Viscosity
This end point was considered for waiver since viscosity is an inherent property of a liquid that offers resistance to its flow and 2-chloro-p-phenylenediamine is a solid substance and hence this testing was considered scientifically unjustified for 2-chloro-p-phenylenediamine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.