Registration Dossier
Registration Dossier
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EC number: 200-911-5 | CAS number: 75-87-6
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: Refer principle below
- Principles of method if other than guideline:
- The Hydrolysis of test chemical was determined
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Analytical monitoring:
- not specified
- Transformation products:
- yes
- No.:
- #1
- Remarks on result:
- other: very little test chemical recovered
- Remarks on result:
- other: 3.6X10-5 equilibrium constant
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.
- Executive summary:
Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.
Reference
Description of key information
Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.
Key value for chemical safety assessment
Additional information
Different studies were performed to determine the hydrolysis rate constant and half-life of test chemical and its structurally similar read across chemicals and results are summarized below
In first study from authoritative database the test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis of equilibrium constant value very little test chemical is recovered.
Another study was conducted to determine the half-life of hydrolysis of test chemical by using different buffers namely MOPS and carbonates. The half-life of hydrolysis of test chemical was determined to be 9 days and 15 days with hydrolysis rate constant of 1.1E-3/h and 1.8E-3/h respectively. On the basis of half-life values test chemical is considered to be hydrolysable.
By considering results of both the studies test chemical is considered to be hydrolysable.
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