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EC number: 204-320-3 | CAS number: 119-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
7-anilino-4-hydroxynaphthalene-2-sulphonic acid is likely to be non hazardous by oral route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction is done using QSAR Toolbox version 3.4
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4
- GLP compliance:
- no
- Test type:
- other: Estimated data
- Specific details on test material used for the study:
- Name: 7-anilino-4-hydroxynaphthalene-2-sulphonic acidMolecular Formula: C16H13NO4SMolecular Weight: 315.3477 g/mole SMILES:Oc1cc(S(O)(=O)=O)cc2cc(Nc3ccccc3)ccc12
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 513.8 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50 % mortality observed in treated rats.
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: not classified
- Conclusions:
- Estimated LD50 was considered to be 3513.8 mg/kg bw when rats were treated with 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally.
- Executive summary:
Acute oral toxicity was estimated QSAR Toolbox 3.4. (2016) in rats by using 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally. 50 % mortality were observed in treated rats at 3513.8 mg/kg bw. Therefore, estimated LD50 was considered to be 3513.8 mg/kg bw when rats were treated with 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((("a" or "b" or("c" or "d") ) and("e" and(not "f")) ) and("g" and(not "h")) ) and "i") and("j" and(not "k")) ) and "l") and("m" and(not "n")) ) and("o" and(not "p")) ) and("q" and(not "r")) ) and("s" and(not "t")) ) and("u" and(not "v")) ) and("w" and "x") )
Domain logical expression index: "a"
Referential boundary:The target chemical should be classified as Strong binder, OH group by Estrogen Receptor Binding
Domain logical expression index: "b"
Referential boundary:The target chemical should be classified as AN2 AND AN2 >> Michael-type addition to quinoid structures AND AN2 >> Michael-type addition to quinoid structures >> N-Substituted Aromatic Amines AND AN2 >> Michael-type addition to quinoid structures >> Substituted Phenols by Protein binding by OASIS v1.4
Domain logical expression index: "c"
Referential boundary:The target chemical should be classified as Strong binder, OH group by Estrogen Receptor Binding
Domain logical expression index: "d"
Referential boundary:The target chemical should be classified as AN2 AND AN2 >> Michael-type addition to quinoid structures AND AN2 >> Michael-type addition to quinoid structures >> N-Substituted Aromatic Amines AND AN2 >> Michael-type addition to quinoid structures >> Substituted Phenols by Protein binding by OASIS v1.4
Domain logical expression index: "e"
Referential boundary:The target chemical should be classified as No alert found by DNA binding by OASIS v.1.4
Domain logical expression index: "f"
Referential boundary:The target chemical should be classified as AN2 OR AN2 >> Michael-type addition, quinoid structures OR AN2 >> Michael-type addition, quinoid structures >> Quinones and Trihydroxybenzenes OR AN2 >> Michael-type addition on alpha, beta-unsaturated carbonyl compounds OR AN2 >> Michael-type addition on alpha, beta-unsaturated carbonyl compounds >> Four- and Five-Membered Lactones OR AN2 >> Schiff base formation OR AN2 >> Schiff base formation >> Polarized Haloalkene Derivatives OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2 >> Shiff base formation after aldehyde release OR AN2 >> Shiff base formation after aldehyde release >> Specific Acetate Esters OR AN2 >> Thioacylation via nucleophilic addition after cysteine-mediated thioketene formation OR AN2 >> Thioacylation via nucleophilic addition after cysteine-mediated thioketene formation >> Polarized Haloalkene Derivatives OR Non-covalent interaction OR Non-covalent interaction >> DNA intercalation OR Non-covalent interaction >> DNA intercalation >> Acridone, Thioxanthone, Xanthone and Phenazine Derivatives OR Non-covalent interaction >> DNA intercalation >> Amino Anthraquinones OR Non-covalent interaction >> DNA intercalation >> DNA Intercalators with Carboxamide and Aminoalkylamine Side Chain OR Non-covalent interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines OR Non-covalent interaction >> DNA intercalation >> Polycyclic Aromatic Hydrocarbon and Naphthalenediimide Derivatives OR Non-covalent interaction >> DNA intercalation >> Quinones and Trihydroxybenzenes OR Non-specific OR Non-specific >> Incorporation into DNA/RNA, due to structural analogy with nucleoside bases OR Non-specific >> Incorporation into DNA/RNA, due to structural analogy with nucleoside bases >> Specific Imine and Thione Derivatives OR Radical OR Radical >> Generation of ROS by glutathione depletion (indirect) OR Radical >> Generation of ROS by glutathione depletion (indirect) >> Haloalkanes Containing Heteroatom OR Radical >> Radical mechanism by ROS formation OR Radical >> Radical mechanism by ROS formation >> Five-Membered Aromatic Nitroheterocycles OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical >> Radical mechanism via ROS formation (indirect) >> Acridone, Thioxanthone, Xanthone and Phenazine Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Amino Anthraquinones OR Radical >> Radical mechanism via ROS formation (indirect) >> Conjugated Nitro Compounds OR Radical >> Radical mechanism via ROS formation (indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >> Radical mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Nitroarenes with Other Active Groups OR Radical >> Radical mechanism via ROS formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >> Radical mechanism via ROS formation (indirect) >> Quinones and Trihydroxybenzenes OR Radical >> Radical mechanism via ROS formation (indirect) >> Single-Ring Substituted Primary Aromatic Amines OR Radical >> Radical mechanism via ROS formation (indirect) >> Specific Imine and Thione Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Thiols OR SN1 OR SN1 >> Alkylation after metabolically formed carbenium ion species OR SN1 >> Alkylation after metabolically formed carbenium ion species >> Polycyclic Aromatic Hydrocarbon and Naphthalenediimide Derivatives OR SN1 >> Nucleophilic attack after carbenium ion formation OR SN1 >> Nucleophilic attack after carbenium ion formation >> Specific Acetate Esters OR SN1 >> Nucleophilic attack after diazonium or carbenium ion formation OR SN1 >> Nucleophilic attack after diazonium or carbenium ion formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> Amino Anthraquinones OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> Fused-Ring Primary Aromatic Amines OR SN1 >> Nucleophilic attack after nitrenium ion formation OR SN1 >> Nucleophilic attack after nitrenium ion formation >> Single-Ring Substituted Primary Aromatic Amines OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Conjugated Nitro Compounds OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR SN1 >> Nucleophilic substitution on diazonium ion OR SN1 >> Nucleophilic substitution on diazonium ion >> Specific Imine and Thione Derivatives OR SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> Specific Acetate Esters OR SN2 >> Acylation involving a leaving group after metabolic activation OR SN2 >> Acylation involving a leaving group after metabolic activation >> Geminal Polyhaloalkane Derivatives OR SN2 >> Alkylation, direct acting epoxides and related OR SN2 >> Alkylation, direct acting epoxides and related >> Epoxides and Aziridines OR SN2 >> Alkylation, direct acting epoxides and related after cyclization OR SN2 >> Alkylation, direct acting epoxides and related after cyclization >> Nitrogen and Sulfur Mustards OR SN2 >> Alkylation, direct acting epoxides and related after P450-mediated metabolic activation OR SN2 >> Alkylation, direct acting epoxides and related after P450-mediated metabolic activation >> Polarized Haloalkene Derivatives OR SN2 >> Alkylation, direct acting epoxides and related after P450-mediated metabolic activation >> Polycyclic Aromatic Hydrocarbon and Naphthalenediimide Derivatives OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon atom OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon atom >> Sulfonates and Sulfates OR SN2 >> Alkylation, ring opening SN2 reaction OR SN2 >> Alkylation, ring opening SN2 reaction >> Four- and Five-Membered Lactones OR SN2 >> Direct acting epoxides formed after metabolic activation OR SN2 >> Direct acting epoxides formed after metabolic activation >> Quinoline Derivatives OR SN2 >> DNA alkylation OR SN2 >> DNA alkylation >> Vicinal Dihaloalkanes OR SN2 >> Internal SN2 reaction with aziridinium and/or cyclic sulfonium ion formation (enzymatic) OR SN2 >> Internal SN2 reaction with aziridinium and/or cyclic sulfonium ion formation (enzymatic) >> Vicinal Dihaloalkanes OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate Esters OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation >> Geminal Polyhaloalkane Derivatives OR SN2 >> SN2 at an activated carbon atom OR SN2 >> SN2 at an activated carbon atom >> Quinoline Derivatives OR SN2 >> SN2 at sp3 and activated sp2 carbon atom OR SN2 >> SN2 at sp3 and activated sp2 carbon atom >> Polarized Haloalkene Derivatives OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 >> Nitroarenes with Other Active Groups by DNA binding by OASIS v.1.4
Domain logical expression index: "g"
Referential boundary:The target chemical should be classified as No alert found by DNA binding by OECD
Domain logical expression index: "h"
Referential boundary:The target chemical should be classified as Acylation OR Acylation >> P450 Mediated Activation to Isocyanates or Isothiocyanates OR Acylation >> P450 Mediated Activation to Isocyanates or Isothiocyanates >> Benzylamines-Acylation OR Michael addition OR Michael addition >> P450 Mediated Activation of Heterocyclic Ring Systems OR Michael addition >> P450 Mediated Activation of Heterocyclic Ring Systems >> Furans OR Michael addition >> P450 Mediated Activation of Heterocyclic Ring Systems >> Thiophenes-Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> 5-alkoxyindoles OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Alkyl phenols OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Hydroquinones OR Michael addition >> Polarised Alkenes-Michael addition OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated esters OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated ketones OR Schiff base formers OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal >> Ethylenediamines (including piperazine) OR Schiff base formers >> Direct Acting Schiff Base Formers OR Schiff base formers >> Direct Acting Schiff Base Formers >> Mono aldehydes OR SN1 OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1 >> Nitrenium Ion formation >> Aromatic nitro OR SN1 >> Nitrenium Ion formation >> Primary aromatic amine OR SN1 >> Nitrenium Ion formation >> Secondary aromatic amine OR SN1 >> Nitrenium Ion formation >> Tertiary aromatic amine OR SN2 OR SN2 >> P450 Mediated Epoxidation OR SN2 >> P450 Mediated Epoxidation >> Thiophenes-SN2 OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides by DNA binding by OECD
Domain logical expression index: "i"
Referential boundary:The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY
Domain logical expression index: "j"
Referential boundary:The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O AND Group 16 - Sulfur S by Chemical elements
Domain logical expression index: "k"
Referential boundary:The target chemical should be classified as Group 17 - Halogens Br OR Group 17 - Halogens Cl OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain logical expression index: "l"
Similarity boundary:Target: Oc1cc(S(O)(=O)=O)cc2cc(Nc3ccccc3)ccc12
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain logical expression index: "m"
Referential boundary:The target chemical should be classified as Stable form by Tautomers unstable
Domain logical expression index: "n"
Referential boundary:The target chemical should be classified as Conjugated keto(scy) - 1,5-H shift OR Keto form (5-membered heteroarenes) - 1,3-H shift by Tautomers unstable
Domain logical expression index: "o"
Referential boundary:The target chemical should be classified as Not categorized by Repeated dose (HESS)
Domain logical expression index: "p"
Referential boundary:The target chemical should be classified as 3-Methylcholantrene (Hepatotoxicity) Alert OR Amiodarone (Hepatotoxicity) Alert OR Benzene/ Naphthalene sulfonic acids (Less susceptible) Rank C OR Oxyphenistain (Hepatotoxicity) Alert OR Pirprofen (Hepatotoxicity) Alert by Repeated dose (HESS)
Domain logical expression index: "q"
Referential boundary:The target chemical should be classified as No alert found by Protein binding alerts for skin sensitization by OASIS v1.4
Domain logical expression index: "r"
Referential boundary:The target chemical should be classified as Acylation OR Acylation >> Direct acylation involving a leaving group OR Acylation >> Direct acylation involving a leaving group >> Anhydrides (sulphur analogues of anhydrides) OR Acylation >> Direct acylation involving a leaving group >> Carbamates OR Acylation >> Ester aminolysis or thiolysis OR Acylation >> Ester aminolysis or thiolysis >> Activated aryl esters OR Michael Addition OR Michael Addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael Addition >> Michael addition on conjugated systems with electron withdrawing group >> alpha,beta-Carbonyl compounds with polarized double bonds OR Michael Addition >> Michael addition on quinone type chemicals OR Michael Addition >> Michael addition on quinone type chemicals >> Pyranones, Pyridones (and related nitrogen chemicals) OR Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones OR Schiff base formation OR Schiff base formation >> Pyrazolones and Pyrazolidinones derivatives OR Schiff base formation >> Pyrazolones and Pyrazolidinones derivatives >> Pyrazolones and Pyrazolidinones OR Schiff base formation >> Schiff base formation with carbonyl compounds OR Schiff base formation >> Schiff base formation with carbonyl compounds >> Aromatic carbonyl compounds OR SN2 OR SN2 >> SN2 Reaction at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters and thioesters by Protein binding alerts for skin sensitization by OASIS v1.4
Domain logical expression index: "s"
Referential boundary:The target chemical should be classified as Not known precedent reproductive and developmental toxic potential by DART scheme v.1.0
Domain logical expression index: "t"
Referential boundary:The target chemical should be classified as Arylethanamine-like derivatives (11a) OR Known precedent reproductive and developmental toxic potential OR Non-steroid nucleus derived estrogen receptor (ER) and androgen receptor (AR) OR Non-steroid nucleus derived estrogen receptor (ER) and androgen receptor (AR) >> 4-alkylphenol-like derivatives (2b-3) OR Prostaglandin receptor agonists (3c) OR Steroid nucleus derived ER and AR binders OR Steroid nucleus derived ER and AR binders >> Androgens, anti-androgens (2a-4) OR Toluene and small alkyl toluene derivatives (8a) by DART scheme v.1.0
Domain logical expression index: "u"
Referential boundary:The target chemical should be classified as No alert found by Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain logical expression index: "v"
Referential boundary:The target chemical should be classified as 1,3-Benzodioxoles (Nongenotox) OR Heterocyclic Polycyclic Aromatic Hydrocarbons (Genotox) OR Structural alert for nongenotoxic carcinogenicity OR Structural alerts for both genotoxic and nongenotoxic carcinogenicity OR Substituted n-alkylcarboxylic acids (Nongenotox) by Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain logical expression index: "w"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.58
Domain logical expression index: "x"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.96
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 513.8 mg/kg bw
- Quality of whole database:
- Data is Klimish 2 and from QSAR Toolbox 3.4. (2016)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
Based on Based on the data available for target 7-anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS no 119-40-4) and its read across 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid (CAS no 6099-57-6), C.I. Acid Orange 10 (CAS no 1936-15-8) and 1-Naphthol-4-sulfonic acid sodium salt (CAS no 6099-57-6) are summarized below
Based on prediction done by using QSAR Toolbox 3.4. (2016), acute oral toxicity was estimated in rats by using 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally. 50 % mortality were observed in treated rats at 3513.8 mg/kg bw. Therefore, estimated LD50 was considered to be 3513.8 mg/kg bw when rats were treated with 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally.
In a study conducted by Sustainability Support Services (Europe) AB (2013) for read across, acute oral toxicity was evaluated in Wistar female rats by using 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in the concentration of 2000 mg/kg bw orally by gavage in distilled water and observed for 14 days. No effect on survival, clinical sign and body weight of treated female rats at 2000 mg/kg bw. No gross pathological changes were observed in treated female rata at 2000 mg/kg bw. Therefore, LD50 was considered to be > 2000 mg/kg bw when Wistar female rats were treated with 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid orally by gavage.
In a study conducted by National Toxicology Program (1987) for read across, acute oral toxicity was evaluated in group of five F344/N male and female rats and B6C3F1 male and female mice by using C.I. Acid Orange 10 in the concentration of 600, 1250, 2500, 5000, 10000 and 20000 mg/kg bw orally in feed for 24 hours and observed for 14 days. No mortality at 600, 1250, 2500, 5000, 10000 and 20000 mg/kg bw and no gross pathological changes were observed in treated male and female rats at 20000 mg/kg bw. Therefore, LD50 was considered to be >20000 mg/kg bw when F344/N male and female rats and B6C3F1 male and female mice were treated with C.I. Acid Orange 10 orally by feed for 24 hours.
In a study given by Japan chemical collaborative knowledge database (2016) for read across, acute oral toxicity was evaluated in Crj:CD(SD)IGS group of 5 male and 5 female rats by using 1-Naphthol-4-sulfonic acid sodium salt in the concentration 2000 mg/kg bw orally. No mortality and change in clinical signs, body weight and gross pathology were observed in treated male and female rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw when Crj:CD(SD)IGS male and female rats were treated with 1-Naphthol-4-sulfonic acid sodium salt orally.
Thus, based on weight of evidence for target 7-anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS no 119-40-4) and its read across 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid (CAS no 6099-57-6), C.I. Acid Orange 10 (CAS no 1936-15-8) and 1-Naphthol-4-sulfonic acid sodium salt (CAS no 6099-57-6) is likely to be non hazardous by oral route of exposure.
Justification for selection of acute toxicity – oral endpoint
estimated LD50 was considered to be 3513.8 mg/kg bw when rats were treated with 7-anilino-4-hydroxynaphthalene-2-sulphonic acid orally.
Justification for classification or non-classification
Based on weight of evidence for target 7-anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS no 119-40-4) and its read across 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid (CAS no 6099-57-6), C.I. Acid Orange 10 (CAS no 1936-15-8) and 1-Naphthol-4-sulfonic acid sodium salt (CAS no 6099-57-6) is likely to be non hazardous by oral route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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