Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-851-5 | CAS number: 100-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Column 2 of Annex VIII criteria for skin irritation testing of styrene provide the following adaptations to required testing data:
The study does not need to be conducted if:
· the substance is classified as corrosive to the skin or as a skin irritant, or
· the substance is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5), or
· the substance is flammable in air at room temperature, or
· the substance is classified as very toxic in contact with skin, or
· an acute toxicity study by the dermal route does not indicate skin irritation up to the limit dose level (2 000 mg/kg body weight).
Column 2 criteria of Annex VIII for eye irritation testing of styrene provide the following adaptations to required testing data:
The study does not need to be conducted if:
· the substance is classified as irritating to eyes with risk of serious damage to eyes, or
· the substance is classified as corrosive to the skin and provided that the registrant classified the substance as eye irritant, or
· the substance is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5), or
· the substance is flammable in air at room temperature.
Styrene is a flammable (R10/ Flam. Liq. 3) liquid substance.
Styrene has harmonized at EU level classifications and it is classified as Xi; R36/38 – Irritating to eyes and skin, in accordance with Directive 67/548/EEC, and Skin and Eye Irritant, Hazard Category 2, H315: Causes skin irritation and H319: Causes serious eye irritation, in accordance with the GHS criteria of Regulation (EC) No 1272/2008. Therefore, no further testing for skin and eye irritation properties is required for styrene.
Because of the data on respiratory irritation effects in animal studies and in humans, styrene iss elf-classified as STOT Single Exposure Category 3 substance; H335: May cause respiratory irritation.
From the data available for styrene, it is likely that liquid styrene or high concentrations of styrene vapour in the air may cause irritation of skin, eye or respiratory tract. Moreover, accidental skin and/or eye contact with liquid styrene may take place. However, this scenario could be relevant for occupational settings.
In general, appropriate engineering controls and work practices to reduce employee exposure to the lowest level achievable must be in place with additional suitable skin, eye, face and respiratory protection in work areas and operations with high risks of exposure to styrene.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.