Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 226-267-5 | CAS number: 5337-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
General information: Avoid chance of exposure by any feasible way.
After inhalation: Move the affected person to fresh air. If breathing becomes irregular or ceases, apply mouth-to-mouth resuscitation or artifical respiration immediately. Get medical attention.
After skin contact: Immediately remove contaminated clothing, wash off the skin with plenty of water.
After eye contact: Rinse the eyes with water for several minutes with eyelids open wide. Having rinsed the eyes, obtain ophthalmologic attention as soon as possible.
After swallowing: Wash out the mouth with plenty of water, give plenty of water to drink, then obtain medical attenton immediately.
Information for doctor: The physician must be informed on the time, type and extent of exposure. If needed, show the safety data sheet to the physician.
Fire-fighting measures
Suitable extinguishing media: Available extinguishing media: water spray, extinguishing powder, carbon dioxid, foam.
Unsuitable extinguishing media: Full waterjet are not suitable for extinguishing.
Special hazards arising from the substance or mixture: Substance is combustible. Combustion products: carbonmonoxide/dioxide.
Advice for firefighters: Outdoors stay on the weatherside and extinguish from there. In closed places, and in case of wreck, wear fireproof working clothes and use selfcontained breathing apparatus.
Other information: Class of flammability hazard (according to Hungarian decree): C (flammable)
Accidental release measures
Personal precautions, protective equipment and emergency procedures:
Only the trained personnel in charge is allowed to be present at the site of spilling, wearing the prescribed protective equipments.
Environmental precautions: Hinder the spilled substance from entering the soil, sewers or living water.
Methods and material for containment and cleaning up:
Spilt substance must be enclosed and soaked up by sand or earth, then it must be collected into spare empties and transported to the place of disposal. Wash the contaminated area with plenty of water
Handling and storage
Precautions for safe handling:
Handled it the compliance with good industrial hygiene and safety procedures. Avoid any possibility of direct contact with substance while manipulating.
Conditions for safe storage, including any incompatibilities: Store it in a cool, dry, wellventilated, free from direct sunlight place.
Specific end use(s): Intermediate (phase product of active pharmaceutical ingredient).
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- not regulated
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Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- not regulated
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Marine transport (UN RTDG/IMDG)
- UN number:
- not regulated
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- not regulated
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Exposure controls / personal protection
This intermediate is handled under Strictly Controlled Conditions in accordance with the ECHA REACH Guidance on Intermediates.
The substance is rigorously contained during storage, the packaging is opened only in case of sampling, and when the substance is used in the process. When the substance is put in the reactor, air filtration (99% efficiency) is used along with personal protective equipment. The process is thereafter fully closed; no emission is detected until sampling of the reaction mass. During sampling air filtration (99% efficiency) is used along with personal protective equipment. At the end of the process, during the unloading of the substance and the sampling general air filtration is used along with personal protective equipment.
No occupational limits have been established.
Individual protection measures / personal protective equipment:
The personal protective equipment for the working process are determined by internal standards.
Wear closed protection glasses. Skin protection: sealed, liquid chemical protective clothing. Hand protection: Protective gloves made of nitrile and butyl,neopren,latex. Respiratory protection: respirator with A2 filter type or with more protective filter cartridge.
Stability and reactivity
The substance is stabil at cool, dry place for 12 months.
Chemical stability: stable under normal circumstances.
Possibility of hazardous reactions: May react with substance in section Incompatible materials.
Conditions to avoid: sensitive to the following physical effects: intense light, intense heat.
Incompatible materials: strong mineral acids, strong basics, strong oxidisers.
Disposal considerations
Suggestions for disposal procedures of the substance/product:
Incineration in a special waste incineration plant.
Suggestions for disposal procedures of contaminated packaging (vessels):
Flammable empties must be incinerated in waste increation plant, in compliance with local regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.