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EC number: 233-546-5 | CAS number: 10226-30-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Aquatic toxicity for 48hrs. study was predicted to assess toxic effects of the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Tetrahymena pyriformis in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 1210.713867188 mg/l on the basis of growth inhibition. Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to micro organisms and thus cannot be classified as hazardous as per the CLP criteria.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 210.71 mg/L
Additional information
Various data for the target chemical 6-Chlorohexan-2-one (CAS No. 10226-30-9) and read across were reviewed for toxicity to micro organism endpoint to summarize the following information:
Aquatic toxicity for 48hrs. study was predicted to assess toxic effects of the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Tetrahymena pyriformis in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 1210.713867188 mg/l on the basis of growth inhibition. Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to micro organisms and thus cannot be classified as hazardous as per the CLP criteria.
In experimental study the read across substance 2-Nonanone (Cas no. 821-55-6) indicate that the toxicity to micro-organisms study was conducted onTetrahymena pyriformisfor 48 hrs. Stock solutions of test chemical was prepared in dimethyl sulfoxide (DMSO) at conc. of 2.5, 5, 10, 25 or 50 mg/l. The volume of stock solution added to each test flask did not exceed 0.35 ml, an amount that does not alterTetrahymenapopulation growth. Based on growth inhibition of test organism, the IGC50 value was found to be 449 mg/l. (SAR end QSAR in Environmental Research, Vol. 3, pp. 27-36, 1995)
Other experimental result from Toxicology Methods, Vol. 7, Pg. no. 289-309, 1997 for read across 2-Octanone (Cas no. 111-13-7) indicate that the Toxicity to micro-organisms study was conducted onTetrahymena pyriformisstrain GL for 40 hrs. The assay was conducted in a buffered medium under static conditions.The 50% inhibitory growth concentration in mg/l (IGC50) and the 95% fiducial interval are determined for each test compound. The IGC50 was calculated with the probit procedure. Based on growth inhibition of test organism, the IGC50 value was found to be 181.1 and 90.7 mg/l, respectively.
From overall above available results the it is concluded that the test substance 6-Chlorohexan-2-one (CAS No. 10226-30-9) is non toxic to micro organisms.
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