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EC number: 219-210-0 | CAS number: 2387-03-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 2387-03-3
- Author:
- Danish (Q)SAR Database
- Year:
- 2 016
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
- Principles of method if other than guideline:
- Data is predicted using the Danish (Q)SAR Database
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- EC Number:
- 219-210-0
- EC Name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- Cas Number:
- 2387-03-3
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)
- Reference substance name:
- Yellow 101
- IUPAC Name:
- Yellow 101
- Test material form:
- not specified
- Details on test material:
- Name of test material (as cited in study report): 2-Hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone- Molecular formula (if other than submission substance): C22H16N2O2- Molecular weight (if other than submission substance): 340.38 g/mol- Smiles notation (if other than submission substance): Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance): 1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Structural formula attached as image file (if other than submission substance): No data available- Substance type: Organic- Physical state: No data available- Analytical purity: No data available- Impurities (identity and concentrations): No data available- Composition of test material, percentage of components: No data available- Isomers composition: No data available- Purity test date: No data available- Lot/batch No.: No data available- Expiration date of the lot/batch: No data available- Radiochemical purity (if radiolabelling): No data available- Specific activity (if radiolabelling): No data available- Locations of the label (if radiolabelling): No data available- Expiration date of radiochemical substance (if radiolabelling): No data available- Stability under test conditions: No data available- Storage condition of test material: No data available- Other: No data available
Constituent 1
Constituent 2
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Table: Table showing the domain applicability estimated by four different models i.e, CASE Ultra, Leadscope and SciQSAR & the average domain applicability was given by the fourth model i.e, Battery model.
Battery | CASE Ultra | Leadscope | SciQSAR | |
Sex-Linked Recessive Lethal (SLRL) Test in Drosophila m.
| NEG_IN | NEG_OUT | NEG_IN | NEG_IN |
Where,
IN = inside applicability domain
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negativeThe test compound induces no gene mutation in Drosophila melanogaster, estimated by four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database.Thus, the test was found to be negative.
- Executive summary:
The mutagenic potency of test substance Yellow 101 was estimated by four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database.
Sex Linked Recessive Lethal (SLRL) Test was performed using Drosophila melanogaster as the test animal.
Based on the four different models i.e, Battery, CASE Ultra, Leadscope and SciQSAR used within Danish QSAR database, it was found that the test compound Yellow 101 induces no gene mutation in Drosophila melanogaster.Thus, the test was found to be negative.
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