Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
5.3.-11.3.2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study is performed in accordance to Guideline study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3,4-Ethylenedioxythiophene
- Comercial name. EDOT
- Substance type: pure organic substance
- Physical state: liquid near colourless to pale yellow
- Analytical purity: > 99%
- Lot/batch No.: 091201
- Expiration date of the lot/batch: 21.1.2011
- Storage condition of test material: Keep in dark at room temperature. Stored in amber glass bottles under the argon atmosphere. Minimalize time for handling with substance without protective argon atmosphere as possible. Maximal time without protective atmosphere is 30 min.

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.976
Temp.:
25 °C
pH:
7.1
Remarks on result:
other: +/- 0.336

Applicant's summary and conclusion

Conclusions:
In accordance with the estimated values of log Pow, it was decided to use the HPLC method for partition coefficient determination.

The partition coefficient of the test substance 3,4-Ethylenedioxythiophene is: log P = 1.979 +/- 0.336 (25 °C, pH = 7.1)
Executive summary:
The procedure was performed according to Method A.8, Partition coefficient, Council Regulation (EC) No 440/2008, Published in O.J. L 142, 2008.

In accordance with the estimated values of log POW (1.56 1.02), it was decided to use the HPLC method for partition coefficient determination.

The partition coefficient of the test substance 3,4-Ethylenedioxythiophene is : log P = 1.976 +/- 0.336 (25 °C, pH = 7.1)