Registration Dossier
Registration Dossier
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EC number: 403-240-8 | CAS number: 106264-79-3 DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- EEC B.3
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- EC Number:
- 403-240-8
- EC Name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- Cas Number:
- 106264-79-3
- Molecular formula:
- C9H14N2S2
- IUPAC Name:
- reaction mass of: 3,5-dimethylthio-2,4-toluenediamine 3,5-dimethylthio-2,6-toluenediamine
- Test material form:
- other: clear liquid
- Details on test material:
- purity: 95.14 % diamines
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: No signs. None of the rabbits died throughout the study.
- Gross pathology:
- Effects on organs:
No test article related lesions observed. - Other findings:
- Signs of toxicity (local):
Slight to moderate erythema was observed at 24 hours after initiation of exposure (exposure time was 24 hrs.)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD guideline 402 the acute dermal LD50 was determined to be > 2000 mg/kg. Thus, the test substance can be considered as not acutely toxic via the dermal route.
- Executive summary:
According to OECD Guideline 402 the test material was applied at a dose of 2000 mg/kg to five male and five female rabbits. The substance was left in contact with the skin for 24 hours. None of the rabbits died during the study, slight to moderate erythema was observed in every animal at 24 hours after initiation of exposure. No test article related lesions observed in gross pathology. The acute dermal LD50 was determined to be greater than 2000 mg/kg.
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