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EC number: 440-550-2 | CAS number: 244021-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed following OECD- and EEC-Guidelines under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- ldentity: TKA 40270 (CGPS 345)
Batch no.: NE 3499-019-A
Expiration date: December 31, 2005
Purity: See Analytical Report 140351 27-1; 8,12.2003; Ciba
Specialty Chemicals Inc. Excluded from the GLP
Statement of Compliance
Aggregate state/physical form
under storage conditions: Liquid
Storage conditions: Room temperature (approx. 20 °C) away from
direct sunlight
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, adapted
- Details on inoculum:
- The study was performed with aerobic activated sludge from a wastewater treatment plant (ARA Ergolz II, Füllinsdorf, Switzerland) treating predominantiy domestic wastewater. The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20.1 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- For analysis of the CO2 content, samples were taken an Day 2, 5, 7, 9, 12, 14, 19, 23, 27,28 and 29.
On each sampling day, an aliquot of 5,0 mL was withdrawn from the absorber flask nearest ta the test flask für analysis of inorganic carbon (IC). Additional samples for analysis of IC were withdrawn from the second absorber fiask at the end of the exposure period an Day 28 in order to correct any carry over of CO2.
After sampling an Day 28, the pH was measured in each test flask. Next, 1 mL of concentrated HCI was added to each test flask and the flasks were aerated overnight to drive oft any residual CO2 present. On Day 29, a sample from each absorber flask was withdrawn and analyzed für IC to determine residual CO2 which was present in the test suspensions on Day 28. In this way, any residual CO2 remaining in the test suspensions was determined as the difference between the amount of IC found before and after acidification.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- No preliminary study performed
- Test performance:
- One day before test start (Day -1), between 2400 and 3000 mL of untreated test medium was fllled into 5 liter flasks (amber glass). To each flask
(except for the abiotic control and the abiotic control blank), 90 mL of activated sludge inoculum was added,
For the abiotic control and the abiotic control blank, the untreated test medium was poisoned with mercury dichloride at a concentration of 10 mg/L (3 mL of a stock solution containing 10 g HgCl2/L filled up to 3 liter test medium).
The test media were aerated with CO2 free air overnight to purge the system of carbon dioxide.
On the following day (Day 0), defined amounts of the homogenized test item were weighed and thereafter transferred into the test flasks with 500 or 510 ml test water. For dosage of the reference item, a stock solution containing 770 mg sodium benzoate per 100 mL test water (purged with CO2
free air) was prepared. From this, 10 mL aliquots were added to the corresponding test flasks. Na emulsifiers or solvents were used. The test flasks
were made up to a volume of three liters with test water (purged with CO2 free air). Twa absorber flasks, the first one containing 300 mL of 0.05 M
NaOH and the second one containing 200 mL of 0.05 M NaOH, were connected in series to the exit air line of each test flask.
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- -2.6
- Sampling time:
- 7 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- -3.8
- Sampling time:
- 14 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- -2.8
- Sampling time:
- 23 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- -2.2
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- The percent biodegradation of the reference item was calculated based an a total carbon content (TOC) of 0.58 mg C/mg sodium benzoate.
In the procedure controls, the reference item degraded by an average of 76% by exposure Day 14, thus confirming suitability of the activated siudge (>60% degradation by Day 14). By the end of the test (Day 28), the reference item degraded by an average of 94%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- TKA 40270 (CGPS 345) was not biodegradable under the test conditions within 28 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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