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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-019-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-14 to 2009-04-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Not yet available.
- EC Number:
- 701-019-3
- Molecular formula:
- (Lu(1-x) Cex)3 Al(5-y) Gay O12, x= 0.005-0.05 and y= 0.1-1.5
- IUPAC Name:
- Not yet available.
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): L173
- Substance type: inorganic
- Physical state: solid
- Analytical purity: presumably > 99 %
- Lot/batch No.: DP/SL 040c/09
- Expiration date of the lot/batch: not applicable
- Stability under test conditions: stable
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, 97633 Sulzfeld, Germany
- Age at study initiation: ca. 13 weeks
- Weight at study initiation: 3.0 kg, 3.8 kg, 3.1 kg
- Housing: Semi barrier in an air-conditioned room, housed in ABS - plastic rabbit cages, floor 4200 cm2
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3°C
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 2009-04-09 To: 2009-04-18
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: Untreated right side of the body served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): enough for moistening the test item
- Lot/batch no. (if required): B. Braun Melsungen, lot 8221A121
- Purity: ca. 100 % - Duration of treatment / exposure:
- Initial test: 4h
Main test: 4 h - Observation period:
- For the determination of classification-relevant values, the animals were examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
For the initial test in one animal, the test site was also examined immediately after the patch has been removed. - Number of animals:
- Initial test: 1
Main test: 2 - Details on study design:
- TEST SITE
- Area of exposure: ca. 6 cm²
- Type of wrap if used: non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: All 3 animals
- Time point:
- other: 1 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: All 3 animals
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: All 3 animals
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: All 3 animals
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: All 3 animals
- Time point:
- other: 1 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: All 3 animals
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: All 3 animals
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: All 3 animals
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: All 3 animals
- Time point:
- other: 1 h
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: All 3 animals
- Time point:
- other: 24 h
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: All 3 animals
- Time point:
- other: 48 h
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: All 3 animals
- Time point:
- other: 72 h
- Remarks on result:
- other: no systemic findings, no specific local findings
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not irritant, not corrosive.
- Executive summary:
Under the conditions of the present study, single dermal application of the test item L173 to rabbits at a dose of 0.5 g showed neither irritant nor corrosive effects.
Neither mortalities nor significant clinical signs of toxicity were observed.
In conformity with the criteria for classification and labelling requirements of the CLP-Regulation (as well as the DSD 2001/59/EC), the test item L173 does not have to be classified and has no obligatory labelling requirement for skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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