Benzyl propionate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2015-12-08 to 2016-03-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

1981

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

no

Remarks:

The study was conducted under supervision of a quality assurance unit which had ensured e.g instrumentation validation, reagent/materials certification, analyst certification and providing standard operating procedures.

Type of method:

dynamic method

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.08 hPa

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0.12 hPa

Key result

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

0.74 hPa

Thermal Stability

The test item in a closed glass crucible showed a small exothermic effect in the temperature range of 150 – 200 °C with energy of -10 J/g.

 

Dynamic method: Vapour-liquid equilibrium (VLE)

Within the experiment a vapour pressure curve with 9 data points was measured over a pressure range between 13 to 90 hPa. For control 3 measuring points were evaluated with decreasing pressure. The vapour pressure was measured in the temperature range of 101.7 to 145.4 °C. The measured vapour pressure values together with the measured temperatures are listed below.

 

No.	Temperature / °C	Vapour pressure / hPa	Remark
1	101.7	12.8	measured up
2	113.1	25.2	measured up
3	123.5	40.1	measured up
4	134.2	60.0	measured up
5	140.1	74.8	measured up
6	145.4	89.9	measured up
7	141.5	80.4	measured down
8	136.2	67.2	measured down
9	127.2	49.7	measured down

 

From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation was derived by regression (Microsoft Excel) of the data points to

 

A = 11.1347

B = -2994.80

C = 273.15.

 

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C.

 

Temperature / °C	Vapour pressure / hPa
20	0.08
25	0.12
50	0.74

 

Conclusions:

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure. Vapour pressure of the test item was determined to be 0.08, 0.12, 0.74 hPa at temperatures of 20, 25, 50 °C, respectively.

Executive summary:

The vapour pressure of the test item was determined by dynamic method and calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4.

Before the test on vapour pressure, DSC measurement in a closed glass crucibles under nitrogen was performed up to a temperature of 300 °C with a heating rate of 3 K/min to determine the thermal stability of the test item. The test item showed an exothermic effect in the temperature range of 150 - 200 °C with an energy of - 10 J/g.

The vapour pressure was measured in the temperature range of 101.7 to 145.4 °C. Within the experiment a vapour pressure curve with 9 data points was measured over a pressure range between 13 to 90 hPa. For control 3 measuring points were evaluated with decreasing pressure. Vapour pressure of the test item was determined to be 0.08, 0.12, 0.74 hPa at temperatures of 20, 25, 50 °C, respectively by extrapolation using the Antoine equation.

Description of key information

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure. Vapour pressure of the test item was determined to be 0.08, 0.12, 0.74 hPa at temperatures of 20, 25, 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0.12 hPa

at the temperature of:

25 °C

Additional information

The vapour pressure of the test item was determined by dynamic method and calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4.

Before the test on vapour pressure, DSC measurement in a closed glass crucibles under nitrogen was performed up to a temperature of 300 °C with a heating rate of 3 K/min to determine the thermal stability of the test item. The test item showed an exothermic effect in the temperature range of 150 - 200 °C with an energy of - 10 J/g.

The vapour pressure was measured in the temperature range of 101.7 to 145.4 °C. Within the experiment a vapour pressure curve with 9 data points was measured over a pressure range between 13 to 90 hPa. For control 3 measuring points were evaluated with decreasing pressure. Vapour pressure of the test item was determined to be 0.08, 0.12, 0.74 hPa at temperatures of 20, 25, 50 °C, respectively by extrapolation using the Antoine equation.