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Diss Factsheets
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EC number: 600-735-2 | CAS number: 106276-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-GLP non-guideline study, available as unpublished report, predates implementation of GLP and/or development of study guidelines, notable limitations in design and/or reporting. After application eye lids were held open for a few seconds instead of closed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The procedure adopted was the technique described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO).
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
Test material
- Reference substance name:
- Mixture of octachloro, monomethoxy-heptachloro and bismethoxy-hexachloro derivatives of 3,3'-[(2-methyl-1,3-phenylene)diimino]bis[2,3-dihydro-1H-isoindol-1-one]
- EC Number:
- 600-735-2
- Cas Number:
- 106276-79-3
- Molecular formula:
- Mixture of C23H8Cl8N4O2, C24H11Cl7N4O3, C25H14Cl6N4O4
- IUPAC Name:
- Mixture of octachloro, monomethoxy-heptachloro and bismethoxy-hexachloro derivatives of 3,3'-[(2-methyl-1,3-phenylene)diimino]bis[2,3-dihydro-1H-isoindol-1-one]
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Russion breed
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: single housing in V2A wire cages
- Diet: NAFAG, Gossau SG, rabbit food ad libitum
- Water: water ad libitum
- Only rabbits showing normal ophthalmic findings were included in the test.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated right eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- Eyes of 3 female animals were rinsed 30 seconds after treatment. Eyes of 3 male animals were not rinsed.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 animals: 3 males, 3 females
- Details on study design:
- Amounts of 0.1 g of the test substance were introduced into the conjunctival sac of the left eye with a spatula. After application, the eyelids were held open for a few seconds. The right eye served as a control. The treated eyes of three female rabbits were each rinsed with 10 mL lukewarm water about 30 seconds after treatment.
SCORING SYSTEM: The reactions were appraised after 24 hours and after 2, 3, 4 and 7 days on the basis of the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the AFDO.
Evaluation of the Eye Reactions:
Cornea:
A. Opacity-degree of density (area most dense taken for reading):
No opacity; 0
Scattered or diffuse area, details of iris clearly visible; 1
Easily discernible translucent areas, details of iris slightly obscured; 2
Opalescent areas, no details of iris visible, size of pupil barely discernible; 3
Opaque, iris invisible; 4
B. Area of cornea involved:
One quarter (or less) but not zero; 1
Greater than one quarter, but less than half; 2
Greater than half, but less than three quarters; 3
Greater than three quarters, up to whole area; 4
A X B X 5
Total maximum = 80
Iris
A. Values
Normal; 0
Folds above normal, congestion, swelling, circumcorneal injection (any or all of these or combination of any thereof) iris still reacting to light (sluggish reaction is positive); 1
No reaction to light, hemorrhage, gross destruction (any or all of these); 2
A x 5
Conjunctivae:
A. Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris):
Vessels normal; 0
Vessels definitely injected above normal; 1
More diffuse/ deeper crimson red, individual vessels not easily discernible; 2
Diffuse beefy red; 3
B. Chemosis:
No swelling; 0
Any swelling above normal (includes nictitating membrane); 1
Obvious swelling with partial eversion of lids; 2
Swelling with lids about half closed; 3
Swelling with lids about half closed to completely closed; 4
C. Discharge:
No discharge; 0
Any amount different from normal (does not include small amounts observed in inner canthus of normal animals); 1
Discharge with moistening of the lids and hairs just adjacent to lids; 2
Discharge with moistening of the lids and hairs, and considerable area around the eye; 3
(A + B + C) X 2
Total maximum = 20
TOOL USED TO ASSESS SCORE: slit-lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 80
- Remarks on result:
- other: Rinsed eye
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 10
- Remarks on result:
- other: Rinsed eye
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 20
- Remarks on result:
- other: Rinsed eye
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 80
- Remarks on result:
- other: Eyes not rinsed
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 10
- Remarks on result:
- other: Eyes not rinsed
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hour - 7 days
- Score:
- 0
- Max. score:
- 20
- Remarks on result:
- other: Eyes not rinsed
- Irritant / corrosive response data:
- The irritation index was found to be 0 for the cornea, 0 for the iris and 0 for the conjunctivae.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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