Tin sulfide (Sn2S3)

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: Expert Statement

Adequacy of study:

key study

Study period:

2015-11-23

Data source

Reference

Reference Type:

other: Expert Statement

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

tin(4+) λ²-tin(2+) trisulfanediide

EC Number:

810-388-0

Cas Number:

12067-23-1

Molecular formula:

Sn2S3

IUPAC Name:

tin(4+) λ²-tin(2+) trisulfanediide

Applicant's summary and conclusion

Conclusions:

Interpretation of results: no bioaccumulation potential based on study results

Executive summary:

Based on the physical form and low water solubility, but mainly on the absence of toxicity in acute and repeated dose oral toxicity studies, oral absorption of tin sulfides and in this case ditin trisulfide (Tin (II,IV) sulfide) is assumed to be very low. This conclusion is confirmed by the literature on oral absorption of inorganic tin compounds.

 

Due to the physical state, the molecular weight, the low water solubility, the vapour pressure, but mainly the absence of toxicity in acute dermal animal testing and the absence of irritating or corrosive and sensitizing potential the dermal absorption of tin sulfides and in this case ditin trisulfide is assumed to be very low.

 

Even if the particle size and the low water solubility favour the assumption that particle can be absorbed on different stages of the stages of the respiratory tract the low vapour pressure and the tendency of ditin trisulfide particles to agglomerate and depositas well as the absence of clear systemic toxicity in acute toxicity studies with tin sulfides do not favour the respiratory uptake.

 

Based on the low water solubility, but mainly based on the absence of target organs or signs of toxicity in an acute and a repeated dose toxicity study with tin sulfides in rats up to the limit concentration, distribution of tin sulfides and in this case ditin trisulfide was considered minimal. Even if literature describes that tin may accumulate mainly in bones, but also in kidneys, liver and lung this is assumed to be of minor interest for insoluble tin sulfides, e.g. ditin trisulfide,due to the low absorption.

 

There is no direct indication of relevant bioaccumulation potential of tin sulfides, e.g.ditin trisulfide. However, literature describes that tin may accumulate mainly in bones, but also in kidneys, liver and lung. But it has been shown that water soluble tin salts are eliminated within short half-times. Taking into account that absorption of insoluble tin sulfides in this case ditin trisulfideis considered to be very low, accumulation is not considered to be relevant.

 

The oral absorptionof tin sulfides and in this case ditin trisulfideis very low, therefore the estimated favoured excretion route is the faecal route. However, very small quantities of absorbed and therefore dissolved parts are excreted via urine and bile. This is confirmed by literature.