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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 942-764-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For oral, dermal and inhalation route, the default values from the REACH guidance (Chapter 8, R.8.4.2) are used fro DNEL derivation: 100% for inhalation, 50% for oral and 50% for dermal.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
In accordance with Annex VIII (point 8.8) of Regulation (EC) No 1907/2006 (REACH), a paper-based toxicokinetic assessment has been conducted for the item, 1,3 -isobenzofuradione, reaction product with DETA. Summaries of studies were reviewed by a
qualified toxicologist with a view to fulfilling the requirements of Annex VIII, point 8.8 of REACH. The list of data used for the assessment is given in section 5. The assessment of the likely toxicokinetic behaviour of the item was provided to the extent that can be
derived from the relevant available information at the time of the assessment. The assessment is based on the Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (ECHA, November 2012). The assessment was conducted in June 2015.
The test item is a yellow powder as listed in Section 2.1. The low vapour pressure value (6.7 E-5 Pa at 25 ºC) and predicted negative explosive and oxidising properties shows that the substance is of low volatility therefore inhalation is not a significant route of exposure. Thsi is confirmed by an acute inhalation study that did not induce mortality in rats. The test item was not indicated to be a sensitizer. The results from the repeated dose reproductive screening study in rats (Rashid, 2014) did not produce any sign of systemic toxicity at 1000 mg/kg bw/day, and there was no effect on offspring survival, growth and development rates to a dosage of 1000 mg/kg bw/day.
Water soluble substances may readily dissolve into the gastro intestinal fluids. However. absorption of very hydrophilic substances by passive diffusion may be limited by the rate at which the substance partitions out of the gastrointestinal fluid. This seems to be confirmed by the absence of any sign of systemic toxicity observed during a repetaed dose toxicity study. However, mortality observed at very high dose levels in acute toxicity studies proves that the substance is able to be absorbed by the gastointestinal tract. The high water solubility and log Pow value suggests that the substace may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Furthermore, in the available acute dermal toxicity study no effects were observed. Therefore, dermal uptake will be very unlikely. For oral, dermal and inhalation route, the default factor values from the REACH guidance (Chapter 8, R.8.4.2) are used fro DNEL derivation: 2 for inhalation, 1 for oral and 1 for dermal.
There is no evidence to indicate the route of excretion but water-soluble products are favourable for urinary excretion and therefore this route may be the major route of excretion of the substance. Biliary excretion may be also considered to be a plausible route of excretion of the test item via the faeces.
The available information suggests that some absorption of the test substance would take place from the gastrointestinal tract. Some limited absorption may also be possible through the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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