Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 478-250-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Acute toxic class)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: Rat (CD)
Administration / exposure
- Vehicle:
- other: 1% w/v aqueous methylcellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Mortality:
- Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3 - Clinical signs:
- Signs of toxicity related to dose levels:
All females dosed at 2000 mg/kg were found dead on Day 2.
Clinical signs prior to death comprised partially closed
eyelids (both) and flat posture seen in all animals. In
addition, piloerection, hunched posture, underactivity,
reduced body temperature, post dose salivation, abnormal
gait (uncoordination), tremors, convulsions and irregular
respiration were seen in two females. Abnormal gait
(unsteady), dark extremities, lacrimation and salivation
were seen in one female. These signs were first observed
from approximately seventeen minutes after dosing. A loss in
bodyweight was recorded for two decedents.
Clinical signs of reaction to treatment in animals which
were dosed at 300 mg/kg comprised hunched posture,
piloerection, abnormal gait (unsteady), seen in all six
females. In addition, underactivity, poor righting reflex,
fast respiration and reduced body temperature, were seen in
four females. FasciculationÆs were seen in three females,
lacrimation, tremors (tremors only during handling) and
partially closed eyelids (both) were seen in two animals,
dark extremities and salivation were seen in one female.
These signs were first observed approximately 30 minutes
after dosing and recovery, as judged by external appearance
and behaviour, by Day 2.
All surviving animals were considered to have achieved
satisfactory bodyweight gains throughout the study. - Gross pathology:
- Effects on organs:
Macroscopic examination of the decedents treated at 2000
mg/kg revealed congestion (characterised by darkened
tissues/organs or blood vessels injected) of the brain,
liver, stomach, duodenum, caecum, small and large intestines
in all animals, subcutaneous tissue, heart, lungs and
spleen was seen in two animals. In addition, small (atrophy)
heart in one animal, pallor of the kidneys in two animals
and white/yellow contents of the stomach, duodenum, caecum,
small and large intestines seen in two/three animals.
No abnormalities were seen in the surviving animals at the
macroscopic examination at study termination on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.