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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin:
The substance is considered to be mildly irritating to rabbit skin.
Eye:
Instillation of the substance into rabbit eye elicited positive response in all 9 treated animals. Irrigation of the eyes, 4 or 30 seconds after instillation did not reduce the irritant potential of the substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 29 October to 01 November 2985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- this study was performed before the amendment of Annex VII and VIII
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no reading at 48 hours
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Lot No.: 6032505
Purity: not specified - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield rabbits, Petersfield, England.
- Age at study initiation: 10-13 weeks
- Weight at study initiation: 2.2-3.1 kg
- Housing: individually housed in metal cages with perforated floors
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C
- Humidity (%): 30-70%
- Air changes (per hr): 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hour period - Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: 2.5 cm square gauze pad to one intact and one abraded skin site on each animal.
- Type of wrap if used: "Elastoplast" elastic adhesive dressing backed with "Sleek" plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): occlusive dressing and gauze pads removed and treatment sites wiped to remove residual test substance.
- Time after start of exposure: 24 hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): 24 and 72 hours after application of test substance
SCORING SYSTEM:
- Method of calculation: Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24/72 hours
- Score:
- 0.45
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24/72 hours
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Very slight erythema was observed in six intact and five abraded sites at the 24 hours reading.
These reactions had resolved completely by the 72 hours reading. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is considered to be mildly irritating to rabbit skin.
- Executive summary:
The study is performed to assess skin irritation potential of the substance to rabbit, according to test method similar with OECD Guideline 404 with some deviations.
The substance is considered to be mildly irritating to rabbit skin.
Reference
Dermal reactions:
Rabbit number | E=Erythema O=Oedema | 24 hours | 72 hours | ||
Intact | Abraded | Intact | Abraded | ||
703 | E O | 1 0 | 1 0 | 0 0 | 0 0 |
825 | E O | 1 0 | 1 0 | 0 0 | 0 0 |
833 | E O | 1 0 | 0 0 | 0 0 | 0 0 |
841 | E O | 1 0 | 1 0 | 0 0 | 0 0 |
868 | E O | 1 0 | 1 0 | 0 0 | 0 0 |
870 | E O | 1 0 | 1 0 | 0 0 | 0 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21 April to 02 June 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Lot No.: 6032505
Purity: not specified - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Buckmasters, Henham and Interfauna Ltd., England
- Age at study initiation: 11-14 weeks
- Weight at study initiation: 2.4-3.2 kg
- Housing: individually housed in metal cages with perforated floors
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C
- Humidity (%): 30-70%
- Air changes (per hr): 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hour period - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- 4 or 30 seconds
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3 for no rinse; 3 for rinse after 4 seconds; 3 for rinse after 30 seconds
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed gently with water for 5 minutes
- Time after start of exposure: 4 or 30 seconds
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: handheld torch
Observations time: after 1 hour and 1, 2, 3, 4, 7, 14 and 21 days after instillation. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.44
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritant / corrosive response data:
- Eyes no rinse:
All three animals gave positive response.
Corneal opacities developed in all 3 animals. Vascularization was seen in one animal.
Iridial inflammation was observed in two animals.
A diffuse crimson red colouration of the conjunctivae was seen in two animals. Considerable swelling with partial eversion of the eyelids was seen in one animal. The eyes of two animals were normal seven days after instillation.
Eyes rinsed after 4 seconds:
All three animals gave positive response.
Corneal opacities developed in all 3 animals. Vascularization was seen in two animals.
Iridial inflammation was observed in two animals.
A diffuse crimson red colouration of the conjunctivae was seen in two animals accompanied by considerable swelling with partial eversion of the eyelids. The eyes were normal seven or 14 days after instillation.
Eyes rinsed after 30 seconds:
All three animals gave positive response.
Corneal opacities developed in all 3 animals. Iridial inflammation was observed in two animals.
A diffuse crimson red colouration of the conjunctivae was seen in all 3 animals accompanied by considerable swelling with partial eversion of the eyelids. The eyes were normal seven days after instillation. - Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Instillation of the substance into rabbit eye elicited positive response in all 9 treated animals. Irrigation of the eyes, 4 or 30 seconds after instillation did not reduce the irritant potential of the substance.
- Executive summary:
The study is performed to assess eye irritation potential of the substance to rabbit, according to OECD Guideline 405.
Instillation of the substance into rabbit eye elicited positive response in all 9 treated animals. Irrigation of the eyes, 4 or 30 seconds after instillation did not reduce the irritant potential of the substance.
Reference
Scores for eyes not rinsed:
Rabbit number | Eye region | Time | ||
24 h | 48 h | 72 h | ||
1830 | Cornea | 1 | 3 | 3 |
Iris | 1 | 1 | 1 | |
Conjunctivae redness | 1 | 2 | 2 | |
Chemosis | 2 | 1 | 2 | |
1834 | Cornea | 2 | 2 | 0 |
Iris | 0 | 0 | 0 | |
Conjunctivae redness | 1 | 1 | 1 | |
Chemosis | 1 | 0 | 0 | |
3062 | Cornea | 1 | 1 | 0 |
Iris | 0 | 0 | 0 | |
Conjunctivae redness | 1 | 2 | 2 | |
Chemosis | 1 | 1 | 1 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation / corrosion:
In vivo skin irritation, key study, OECD 404:
Mean score for erythema at 24, 72 h for 6 animals: 0.45
Mean score for edema at 24, 72 h for 6 animals: 0
According to Regulation (EC) No 1272/2008, table 3.2.2, this substance should not be classified for this endpoint.
Eye irritation:
In vivo eye irritation, key study, OECD 405:
Mean scores for cornea opacity, iris, conjunctivae and chemosis at 24, 48, and 72h: 1.44, 0.33, 1.33, 1. And the severe effects were not fully reversed within 21 days.
Therefore, according to Regulation (EC) No 1272/2008, table 3.3.1, this substance should be classified as Cat 1 Irreversible effects on the eye.
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