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EC number: 248-792-9 | CAS number: 28043-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study following a method equivalent to a recognised guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.42
- Deviations:
- no
- Principles of method if other than guideline:
- The method was in accordance with the 16 CFR 1500.42 and US CPSC requirements
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- EC Number:
- 248-792-9
- EC Name:
- Methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- Cas Number:
- 28043-10-9
- Molecular formula:
- C11H18O2
- IUPAC Name:
- methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino ; not otherwise specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Recognised supplier.
- Age at study initiation: Young adults.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 grammes
- Concentration (if solution): neat (unchanged) - Duration of treatment / exposure:
- 3 days
- Observation period (in vivo):
- 4 days (observations were completed every day from day 1 to day 7 post treatment).
- Number of animals or in vitro replicates:
- 6 (sexes not specified)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No.
SCORING SYSTEM: Draize scoring system. Reference 16 CFR 1500.42.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 24
- Remarks on result:
- other: n = 6; maximum category score = 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 24
- Remarks on result:
- other: n = 6; maximum category score = 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 12
- Remarks on result:
- other: n =6; maximum category score = 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 12
- Remarks on result:
- other: n =6 ; maximum category score = 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 18
- Remarks on result:
- other: n =6 ; maximum category score = 3; conjunctivae redness - maximum score = 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 18
- Remarks on result:
- other: n =6 ; maximum category score = 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 24
- Remarks on result:
- other: n =6 ; maximum category score = 4; chemosis - maximum score = 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 24
- Remarks on result:
- other: n =6 ; maximum category score = 4; chemosis - maximum score = 0
- Irritant / corrosive response data:
- Following scoring at 24, 48 and 72 h: No positive corneal scores. No positive iridal scores. No positive conjunctivae redness mean scores. No positive chemosis mean scores. All scores for all effect categories were < 1 in all animals on all days (24 to 72hs; and up to 7 days). Discharge positive scores were also absent.
Any other information on results incl. tables
Individual scoring data was presented within the study report. No positive responses observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
- Conclusions:
- Under the conditions of this study the test substance would not be considered as an eye irritant.
- Executive summary:
- The GLP study was completed under 16 CFR 1500.42 following a guideline similar to OECD 405, to assess the irritancy potential of the test material to the eye following a single application in the albino rabbit. A mass of 0.1 grams of the test material was placed into one eye in each of 6 animals. The other eye remained untreated and was used for control purposes. Assessment of ocular damage/irritation was made approximately 24, 48 and 72 hours following treatment with observations daily up to 7 days. No corneal opacity or iritis, chemosis or conjunctival redness as observed at any time point up to 7 days in all animals. Under the conditions of this study the test material is not considered to be an eye irritant.
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