complex reaction mass of Chinese gum rosin post reacted with acrylic acid

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP - Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

Sponsors identification: ARAKAWA KE-604
Description: pale yellow blocks
Batch No.: R61132
Purity: no data

Results and discussion

Partition coefficient

Type:

log Pow

Partition coefficient:

>= 6.04

Any other information on results incl. tables

Partition coefficient of the sample: the retention times, capacity factors and Log Pow values are shown in the following table

Component	Injection	Retention time (mins)	Capacity factor (k)	Log10k	Log10Pow
A	1 2	71.300 71.178	26.465 26.418	1.423 1.422	6.05 6.04
B	1 2	79.880 79.816	29.770 29.746	1.474 1.473	>6.2 >6.2

 

Component A

Mean Log₁₀P_ow= >6.04

Partition coefficient = >1.11 x 10⁶

Component B

Mean Log₁₀P_ow= >6.2

Partition coefficient = >1.59 x 10⁶

 

Overall (Component A & B)

Log₁₀P_ow= >6.04

Partition coefficient = >1.10 x 10⁶

^{In order to determine the partition coefficent of the test material in its unionized form, the pH of the mobile phase was adjusted to 2.6.}

Applicant's summary and conclusion

Executive summary:

The partition coefficient of Arakawa KE-604 was determined to be greater than 1.10 x 10⁶, Log₁₀P_ow >6.04.