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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethylamine
EC Number:
200-574-4
EC Name:
Phenethylamine
Cas Number:
64-04-0
Molecular formula:
C8H11N
IUPAC Name:
2-phenylethanamine
Test material form:
liquid
Details on test material:
Name of the test substance used in the study report: 2-Phenylaethylamin

Test animals

Species:
rat
Strain:
other: Gassner rats
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
The test concentrations used wsere 2, 4, 8 and 20% V/V; aqueous emulsion with Traganth.
Doses:
200 (2x), 320, 400, 800, 1600 mm³/kg
No. of animals per sex per dose:
20 per dose level
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 287 mg/kg bw
Remarks on result:
other: original value: ca. 300 mm3/kg
Mortality:
200 mm3/kg (2x): 0/20 after 7 days
320 mm3/kg: 14/20 after 7 days
400 mm3/kg: 18/20 after 7 days
800 and 1600 mm3/kg: 20/20 after 7 days
Clinical signs:
other: Apathy, dyspnea, severe spasms, reverse running (like neurolathyrism).
Gross pathology:
Nothing abnormal detected.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria