Registration Dossier
Registration Dossier
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EC number: 231-639-5 | CAS number: 7664-93-9
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: Review
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary of published data
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for 11th SIAM
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP Publications
Materials and methods
- Study type:
- other: summary of health effects
- Endpoint addressed:
- acute toxicity: inhalation
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- : not applicable
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
Constituent 1
Method
- Details on study design:
- The OECD SIDS briefly summarises the available data on the effects of human exposure to sulphuric acid
Results and discussion
- Results:
- Inhalation exposure to sulphuric acid is known to cause effects on the respiratory tract and teeth.
Any other information on results incl. tables
Acute inhalation exposure to sulphuric acid aerosols causes a range of effects in the respiratory system including decrease in particle clearance rates at lower concentrations ( 1.0 mg/m3) to changes in lung function (>1.0 mg/m3). Asthmatics and those with hyper-reactive airways appear more sensitive to the broncho-constrictive effects of the aerosol. Repeated exposure to higher concentrations of aerosol (>3.0 mg/m3) has been reported to cause damage to the incisors.
Applicant's summary and conclusion
- Conclusions:
- Inhalation exposure to sulphuric acid is known to cause effects on the respiratory tract and teeth.
- Executive summary:
Acute inhalation exposure to sulphuric acid aerosols causes a range of effects in the respiratory system including decrease in particle clearance rates at lower concentrations ( 1.0 mg/m3) to changes in lung function (>1.0 mg/m3). Asthmatics and those with hyper-reactive airways appear more sensitive to the broncho-constrictive effects of the aerosol. Repeated exposure to higher concentrations of aerosol (>3.0 mg/m3) has been reported to cause damage to the incisors.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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