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Diss Factsheets
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EC number: 203-474-9 | CAS number: 107-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test was conducted according to a BASF internal test method, which in principle was similar to OECD 404, however with following deviations: Exposure periods of 1, 5,15 minutes and 20 h (OECD recommendation: 4 h); Testing of the ear (not recommended by the OECD guideline); Time point 72 h not considered; Observation period of 8 days instead of 14 as recommended by OECD guideline. These deviations did not affect the validity and reliability of the findings; the study is scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (1981)
- Principles of method if other than guideline:
- The test was conducted according to an internal BASF test method, which in principle was similar to OECD 404.
BASF-TEST:
White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5, 15 min and 20 h using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the liquid test substance. In addition, skin tissue from the ear was tested by wrapping the ear. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal/lateral flank of the back. After the application time, the skin was washed with water which sometimes contained a mild detergent. The animals were observed for 8 days. Skin reaction was recorded after 1h, 24h, 48h, 72h, 96h and after 7 and 8 days. - GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted
Test material
- Reference substance name:
- Glyoxal
- EC Number:
- 203-474-9
- EC Name:
- Glyoxal
- Cas Number:
- 107-22-2
- Molecular formula:
- C2H2O2
- IUPAC Name:
- oxalaldehyde
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: none as the test substance was applied unchanged
- Controls:
- other: untreated skin of the same animal served as control
- Amount / concentration applied:
- the test substance was applied undiluted to the skin using a patch soaked with test material; the applied amount was about 1 mL.
- Duration of treatment / exposure:
- Dorsal skin: 1, 5, 15 min
Dorsal skin: 20 h
Ear: 20 h - Observation period:
- The animals were observed following exposure for 8 days on working days. Skin changes were recorded after removal of the bandage as well as after 1h, 24h, 48h, 72h, 96 h and after 7 and 8 days.
- Number of animals:
- Four animals were used.
- Details on study design:
- - Each animal received an application of test material to the clipped dorsal skin of the trunk and to the ear. The test material was used unchanged at a volume of 1 mL and the application site was maintained under occlusive conditions.
-Following application periods of 1, 5 and 15 minutes (dorsal skin), dressing was removed and the application site was rinsed with Lutrol and Lutrol in water (1:1).
- Following application periods of 20 hours (dorsal skin and ear), the dressing was removed but the application site was not rinsed. The animals were observed and skin findings were recorded over a period of 8 days following treatment.
-The skin findings, which had been originally scored according to a BASF scoring system, were re-scored according to the OECD Draize scoring system; for this purpose, only the findings of the 20-hour dorsal application were considered at the time point 24 and 48 hours (no 72 h data provided).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1 min and 5 min exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks:
- distinct scaling
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks:
- necrosis
- Irritation parameter:
- edema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks:
- distinct scaling
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Remarks:
- necrosis
- Other effects:
- - After 1 and 5 minutes: at reading time point 24 hour, slight erythema was seen; full reversibility was reported for day 8.
- After 15 minutes: at reading time point 24 hours, slight edema and slight erythema were observed; at day 8 fine scaling was seen, indicating partial reversibility.
- After 20 hours: erythema, edema and slight skin defects were seen within 24 h; eschar formation and slight necrosis were seen within 8 days.
Any other information on results incl. tables
The 20-hour dorsal treatment which was relevant for assessment resulted in erythema and edema; after 8 days, severe necrosis was seen, indicating no reversibility.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
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