Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-170-3 | CAS number: 1309-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- Principles of method if other than guideline:
- Description of a poisoning incident with magnesium sulphate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Magnesium sulphate
- EC Number:
- 231-298-2
- EC Name:
- Magnesium sulphate
- Cas Number:
- 7487-88-9
- Molecular formula:
- H2O4S.Mg
- IUPAC Name:
- Magnesium Sulphate
Constituent 1
Method
- Type of population:
- general
- Subjects:
- .
- Ethical approval:
- not specified
- Route of exposure:
- oral
- Reason of exposure:
- intentional
Results and discussion
Any other information on results incl. tables
A 38-year-old white woman had a mason-type operation seventeen months previously. She had recently had a barium enema during investigation of lower abdominal pain. Two tablespoons of Epsom salts (70 g magnesium sulphate) were taken for bowel preparation, as instructed. They were taken with half a cup of lukewarm water, followed by a small amount of orange juice. Within ten minutes of taking the purgative, she experienced a feeling of "internal heat" followed by prostration. Severe hypotonia, absence of peripheral reflexes, slurred speech, blood pressure 115/75 mm Hg, pulse rate 60/min and cold, clammy skin, increased intestinal motility, vomiting and respiratory depression were noted. On arrival at the casualty department a blood sample was taken and again seventeen hours later. She was treated with 15 ml of calcium gluconate intravenously upon admission.
A blood sample showed a serum magnesium level of 2.93 mmol/L. This fell to 1.3 mmol/L seventeen hours later (normal value < 1.0 mmol/L). On administration of calcium gluconate her clinical condition improved dramatically within the next few minutes.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, magnesium poisoning was observed in a patient who was administered 70 g magnesium sulphate having previously undergone a Mason-type gastric operation.
- Executive summary:
In a poisioning incident described by Aucamp et al., a 38-year-old white woman had a mason-type operation seventeen months previously. She had recently had a barium enema during investigation of lower abdominal pain. Two tablespoons of Epsom salts (70 g magnesium sulphate) were taken for bowel preparation, as instructed. They were taken with half a cup of lukewarm water, followed by a small amount of orange juice. Within ten minutes of taking the purgative, she experienced a feeling of "internal heat" followed by prostration. Severe hypotonia, absence of peripheral reflexes, slurred speech, blood pressure 115/75 mm Hg, pulse rate 60/min and cold, clammy skin, increased intestinal motility, vomiting and respiratory depression were noted. On arrival at the casualty department a blood sample was taken and again seventeen hours later. She was treated with 15 ml of calcium gluconate intravenously upon admission.
A blood sample showed a serum magnesium level of 2.93 mmol/L. This fell to 1.3 mmol/L seventeen hours later (normal value < 1.0 mmol/L). On administration of calcium gluconate her clinical condition improved dramatically within the next few minutes.
In conclusion, magnesium poisoning was observed in a patient who was administered 70 g magnesium sulphate having previously undergone a Mason-type gastric operation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.