Registration Dossier
Registration Dossier
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EC number: 400-830-7 | CAS number: 104810-48-2 EVERSORB 80; TINUVIN 1130; TINUVIN 213
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- EC Number:
- 400-830-7
- EC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- Cas Number:
- 104810-48-2
- IUPAC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: vaseline
- Concentration / amount:
- Induction: 1 % (intradermal) in sesame oil and in adjuvant mixture; 10 % (epidermal) in vaseline
Challange: 1 % (epidermal) in vaseline
Challengeopen allclose all
- Route:
- other: epidermal
- Vehicle:
- other: vaseline
- Concentration / amount:
- Induction: 1 % (intradermal) in sesame oil and in adjuvant mixture; 10 % (epidermal) in vaseline
Challange: 1 % (epidermal) in vaseline
- No. of animals per dose:
- 20 animals in test group
20 animals in negative control group
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 1 %(epidermal) in vaseline
- No. with + reactions:
- 14
- Total no. in group:
- 20
- Remarks on result:
- other: . Hours after challenge: 24.0. Group: test group. Dose level: 1 %(epidermal) in vaseline. No with. + reactions: 14.0. Total no. in groups: 20.0.
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 1 % (epidermal) in vaseline
- No. with + reactions:
- 10
- Total no. in group:
- 20
- Remarks on result:
- other: . Hours after challenge: 48.0. Group: test group. Dose level: 1 % (epidermal) in vaseline. No with. + reactions: 10.0. Total no. in groups: 20.0.
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
Any other information on results incl. tables
Data incomplete
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- The test material was a strong skin sensitiser in this test.
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