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EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 October 2004 to 2 November 2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- EC Number:
- 255-255-2
- EC Name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- Cas Number:
- 41198-08-7
- Molecular formula:
- C11H15BrClO3PS
- IUPAC Name:
- 4-bromo-2-chlorophenyl ethyl (propylsulfanyl)phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: none
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- 2.2 mg/L
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 2 mg/L
- No. of animals per sex per dose:
- 5 animals/sex/gp
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.2 mg/L air (analytical)
- Based on:
- other: no deaths observed
- Exp. duration:
- 4 h
Any other information on results incl. tables
Mortality:
No deaths were observed.
Clinical observations:
During exposure clinical observations were associated with restraint, including wet fur and salivation. In addition all animals had increased breathing rate.
Post exposure hunched posture and piloerection were observed in one female.
Changes indicative of irritation of the respiratory tract (increased breathing rate and abnormal respiratory noise in some animals) were observed post exposure.
By day 3, post exposure, the clinical condition of the animals had greatly improved, with all animals fully recovered by day 7 of the study.
Bodyweight:
Three males and 1 female had gained weight by day 8 of the study. All males and 2 females had gained weight by the end of the study. The remaining females showed some evidence of weight gain during the study.
Necropsy:
There were no test material related changes observed.
Table 7.2.2-1: Particulate concentration
Target particulate concentration (mg/L) |
Measured particulate concentration (mg/L) Mean ± SD |
2 |
2.20±0.25 |
Table 7.2.2-2: Aerodynamic particle size distribution
Time into exposure |
Median size (MMAD) (um) |
GSD |
62 |
3.51 |
1.65 |
180 |
3.01 |
1.59 |
Applicant's summary and conclusion
- Conclusions:
- Nose only exposure to a particulate concentration of 2.2 mg Profenofos Technical (CGA15324)/L resulted in no deaths and no adverse effects. It is concluded that the LD50 of Profenofos Technical (CGA15324) exceeds 2.2 mg/L.
- Executive summary:
A group of 5 male and 5 female SD rats were exposed nose only for a single 4 hour period to Profenofos Technical (CGA15324) at a target particulate concentration of 2 mg/L. Test atmospheres were analysed for particulate concentration and Profenofos Technical (CGA15324). The particle size distribution of the test atmosphere was analysed twice during the exposure period. Following exposure, the animals were retained without treatment for 14 days. Clinical observations and bodyweights were recorded throughout the study and at the end of the scheduled period, the animals were killed and subjected to a gross examination post mortem.
The achieved test atmospheres had the following characteristics: Achieved concentration: 2.2 mg/L, MMAD 3.51 and 3.01 um, GSD 1.675 and 1.59.
There were no deaths. Transient signs of respiratory irritation were seen in all animals. There were no test material related macroscopic findings observed at necropsy.
Nose only exposure to a particulate concentration of 2.2 mg Profenofos Technical (CGA15324)/L resulted in no deaths and no adverse effects. It is concluded that the LD50 of Profenofos Technical (CGA15324) exceeds 2.2 mg/L.
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