Registration Dossier
Registration Dossier
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EC number: 213-063-6 | CAS number: 921-03-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1997
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD Guideline study result, limited documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,3-trichloroacetone
- EC Number:
- 213-063-6
- EC Name:
- 1,1,3-trichloroacetone
- Cas Number:
- 921-03-9
- Molecular formula:
- C3H3Cl3O
- IUPAC Name:
- 1,1,3-trichloropropan-2-one
- Details on test material:
- - Name of test material (as cited in study report): 1,1,3-Trichloraceton
- Physical state: liquid
- Analytical purity: 85%
- Impurities (identity and concentrations): not mentioned
Constituent 1
Test system
- Vehicle:
- other: DMSO
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 1, 10, 100 mg/l
- Duration of treatment / exposure:
- 60 minutes
- Observation period (in vivo):
- immediately after exposure
- Number of animals or in vitro replicates:
- 3 eggs
- Details on study design:
- HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: HET CAM
- Irritant / corrosive response data:
- not reported
- Other effects:
- not reported
Any other information on results incl. tables
Substance is irritating to eys down to a concentration of 10 mg/l.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane)
- Conclusions:
- Substance is irritating to eyes down to concentrations of 10 mg/l
- Executive summary:
A modified HET-CAM TEST (Hens Egg Test at the Chorion Allantois Membrane) has been used to investigate the mucous membrane irritating effects. 1,1,3 -Trichloroacetone showed irritating effects (not quantified in the literature) dowbn to 10 mg/l.
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