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Diss Factsheets
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EC number: 215-607-8 | CAS number: 1333-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- JUN 1975 - OCT 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Follow-Up Study of Patients with Contact Dermatitis Caused by Chromates, Nickel, and Cobalt
- Author:
- A.Dooms-Goossen
- Year:
- 1 980
- Bibliographic source:
- Dermatologie 160: 249-260
Materials and methods
- Type of sensitisation studied:
- skin
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Short description of test conditions:
1,000 patients (396 males and 604 females) were patch tested at our contact allergy unit with the ÏCDRG standard test battery (Trolle Lassen, Denmark) using Silver-Patch® (Van der Bend, The Netherlands), and Tarpal® (Fisch) hypoallergenic tape. The ICDRG guidelines were followed. All test samples were stored in a refrigerator at 4°C to ensure stability.
- Parameters analysed / observed: The patch test results from 1,000 patients tested with the ICDRG standard series are analyzed for positive reactions to potassium dichromate, nickel sulphate, and cobalt chloride. - GLP compliance:
- no
Test material
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- Cr2H2O7.2K
- IUPAC Name:
- sodium dichromate
- Details on test material:
- Cr (K2Cr2O7)
Constituent 1
Method
- Type of population:
- other: Patients with contact dermatitis
- Ethical approval:
- not applicable
- Subjects:
- - Number of subjects exposed: 1000
- Sex: 396 males and 604 females
- Demographic information: 69 (6.9%) suffered fromeczematous lesions only on their feet, 246 (24.6%) patients with eczema only on their hands, 124 were leg ulcer patients - Clinical history:
- - Exposure history: 69 (6.9%) suffered fromeczematous lesions only on their feet, 246 (24.6%) patients with eczema only on their hands, 124 were leg ulcer patients; 9 of them reacted to potassium dichromate.
- Controls:
- none
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Description of patch: Silver-Patch® (Van der Bend, The Netherlands), and Tarpal® (Fisch) hypoallergenic tape.
- Concentrations: 0.5% (ICDRG test)
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 53
- Number of subjects with negative reactions 947
Positive patch test results to metals obtained from 1,000 patients tested with the ICDRG test series shows 25 of male patients and 28 of female patients, total 53 patients (5.3%) had a positive raction to potassium dichromate.
Positive patch test results from 69 patients with foot dermatitis (32 cases were considered allergic contact dermatoses) shows that 13 of patients (18.8%) had a positive reaction to potassium dichromate.
Positive patch test results from patients with hand eczema (109 cases were considered allergic contact dermatoses) shows 25 patients (10.2%) had a positive reaction to potassium dichromate.
Applicant's summary and conclusion
- Conclusions:
- Positive patch test results to metals obtained from 1,000 patients tested with the ICDRG test series shows 53 of patients (5.3%). Of the 53 patients allergic to potassium dichromate, this allergen was considered relevant to the dermatoses of 46 (87%) of them.
- Executive summary:
1,000 patients (396 males and 604 females) were patch tested at contact allergy unit with the ÏCDRG standard test battery1 (Trolle Lassen, Denmark) using Silver-Patch® (Van der Bend, The Netherlands), and Tarpal® (Fisch) hypoallergenic tape. The ICDRG guidelines were followed. Positive patch test results to metals obtained from 1,000 patients tested with the ICDRG test series shows 53 of patients (5.3%). Of the 53 patients allergic to potassium dichromate, this allergen was considered relevant to the dermatoses of 46 (87%) of them.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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