Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 282-758-4 | CAS number: 84402-58-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50, oral > 2500 mg/kg bw
acute Tox. dermal: test waived (scientifically not justified: not hazardous)
acute Tox. inhalation: test waived (limited exposure)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 1983-06-20 till 1983-09-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without GLP and without deviations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Tif:RAIf(SPF), F3-crosses of RII 1/Tif x RII 2/Tif
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- one single dose, per os
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Statistics:
- not necessary
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- one femal rat, 3 hours after treatment.
- Clinical signs:
- other: The surviving animals recovered within 9 days.
- Gross pathology:
- Besides one case of spotted lung no gross lesions were found at necropsy.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material has practically no acute toxicity when administered orally to the albino rat up to 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
- Quality of whole database:
- All three available studies are guideline studies and with Klimisch score 1 or 2.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- No acute inhalation toxicity study available.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the physicochemical and toxicological properties suggest no potential for a significant rate of absorption through the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- No acute dermal toxicity study but a skin penetration test is available.
Additional information
Three acute oral studies with different technical products (ca. 50% MPAAU in water) showed no oral toxicity to rats up to 5000 mg/kg bw. The oral LD50 of MPAAU was >2500 mg/kg bw. This is further supported by the results of a 7 day dose range-finding study in female rats, which showed no clinical signs up to and including 2000 mg MPAAU/kg bw/day (see IUCLID Chapter 7.5.1).
Based on weight of evidence the substance is deemed to be not hazardous for acute systemic toxicity by the dermal route.
A skin penetration test (see IUCLID Chapter 7.1.2) shows very low penetration of the test material (5% in 24 hours) through the skin of porcine ears. The substance did not show adverse effects in two in vivo 4h skin irritation/corrosion tests (see IUCLID Chapter 7.3.1). In view of the oral LD50>2500 mg/kg and the low skin penetration of the substance no acute systemic hazard can be expected for the dermal route.
Based on weight of evidence (no acute oral toxicity, assumption of similar absorption both by oral and inhalation route, no irritating potential to skin or eye) the substance is considered not hazardous with regard to acute systemic and acute local endpoint toxicity by the inhalation route. In addition, inhalation exposure is unlikely to occure under intended conditions of use (limited exposure).
Justification for selection of acute toxicity – oral endpoint
All three acute oral toxicity studies show no toxicity or adverse effects of the substance. The study with the highest dose tested was chosen to report the (theoretical) limit value.
Justification for selection of acute toxicity – inhalation endpoint
No significant inhalation exposure is expected.
Justification for selection of acute toxicity – dermal endpoint
Based on weight of evidence the substance is deemed to be not hazardous for acute systemic toxicity by the dermal route.
Justification for classification or non-classification
According to the GHS criteria, listed in Annex I, the substance does not have to be classified as a hazardous substance regarding acute toxicity to mammals.
Based on the above stated assessment of the acute toxic potential of MPAAU (oral LD50 > 2500 mg/kg, weight of evidence for absence of acute dermal or inhalation systemic toxicity) the substance is deemed non-toxic for acute systemic endpoints and accordingly does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.