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Diss Factsheets
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EC number: 284-325-5 | CAS number: 84852-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Nonylphenol is not considered to be a PBT substance.
Persistence
Several biodegradability studies carried out in accordance with OECD 301B (Gledhill (1999), Staples (2001)) and OECD 301F (Staples (1999), Stasinakis (2008)) confirmed that nonylphenol was inherently biodegradable and readily biodegradable except for the 10-day window, respectively. Together these data indicate that nonylphenol is likely to degrade and is not considered to be persistent (P) or very persistent (vP). Other factors including mixing, adsorption, abiotic processes, and the presence of particular algal and fungal species have been demonstrated to be important influences in nonylphenol degradation in the aquatic environment. Similarly, nonylphenol is expected to degrade in the sediment and soil compartments.
Bioaccumulation
A weight of evidence (WoE) approach has been taken to the determination of the potential for nonylphenol to bioaccumulate in aquatic organisms and is described in a separate technical report in Section 13 of the CSA. For the purposes of the risk assessment, the BCF of 896 from the Ekelund et al (1990) study with the fish Gasterosteus aculeatus is used. Results of this study show the BCF of valid fish bioconcentration studies are lower than the REACH bioaccumulation criterion of < 2,000.
Toxicity
Ecotoxicity data for aquatic organisms provided a NOEC value of 0.00127 mg nonylphenol/L for fertility in fish (Watanabe et al, 2017) and the NOEC of 0.001 mg nonylphenol/L for invertebrate growth inhibition. Acute, short-term exposures indicated similar sensitivity between freshwater fish and freshwater invertebrates (LC50 for survival of 0.02 to 0.05 mg nonylphenol/L, respectively). These results meet the T criteria for aquatic organisms.
- Likely routes of exposure:
Based on exposure scenarios currently presented, inhalation, dermal and oral routes of exposure are possible. Release to the environment is also considered. However, the exposure scenarios cover the use of nonylphenol derivatives and polymers not within the scope of REACH registration. Considering uses of nonylphenol in the scope of REACH registration, worker exposure via inhalation and dermal exposure can be considered possible, with minimal release to the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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