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Diss Factsheets
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EC number: 271-516-3 | CAS number: 68583-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- 10 day repeated intramuscular irritation study in rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- Decanoic acid, mixed diesters with octanoic acid and propylene glycol
- EC Number:
- 271-516-3
- EC Name:
- Decanoic acid, mixed diesters with octanoic acid and propylene glycol
- Cas Number:
- 68583-51-7
- Molecular formula:
- C21H44O6
- IUPAC Name:
- Waglinol 2/7680
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: no less than 2.5 kg
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.6 mL
- No. of animals per sex per dose:
- 6 (test substance group)
6 (castor oil BP group) - Control animals:
- other: concurrent with castor oil BP
- Details on study design:
- - Two groups were concurrently tested.
- Group 1 was daily treated with the test material.
- Group 2 daily received castor oil BP.
- The injection site was clipped and the skin swapped with alcohol. The test substances were applied intramuscular into the biceps of the right hind leg of each rabbit with a sterile syringe and a 23 gauche x13/16 hypodermic needle.
Results and discussion
Results of examinations
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- GROSS PATHOLOGY
Group 1: Haematoma and/or haemorrhage in 5 of 6 animals, slight discolouration in 3 of 6 animals, 1 of 6 animals showed connective tissue laden with pus.
Group 2: Haematoma and/or haemorrhage in 3 of 6 animals, congestion in 2 of 6 animals, discolouration in 4 of 6 animals, inflammation in 3 of 6 animals, 2 of 6 animals showed connective tissue laden with pus.
HISTOPATHOLOGICAL
Group 1: Chronic inflammatory reaction and degenerative muscle fibres in 5 of 6 animals, in 3 of 6 animals haemorhage and giant cell granulomata were observed.
Group 2: Chronic inflammatory reaction in 5 of 6 and degenerative muscle fibres in 6 of 6 animals, in 1 of 6 animals haemorhage were observed.
UNTREATED TISSUE
All samples of the control muscle (untreated) were found to be within normal limits.
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- <= 0.24 other: mL/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The test substance seems to be irritant to muscles and causes muscle necrosis after repeated injections. Furthermore, some giant cell grunulomate have been observed after repeated treatment. Animals similarly treated with castor oil BP showed more severe effects.
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