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EC number: 911-280-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Sept 1996 to 13 Nov 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with relevant OECD guideline and to GLP standards.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): AMYL SALICYLATE
- Molecular formula (if other than submission substance): C12H16O3
- Molecular weight (if other than submission substance):208.3 g/mol
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type: Mixture of two isomers (ratio not reported)
- Physical state: Liquid
- Analytical purity: 98.5% (sum of two isomers)
- Lot/batch No.: 261891 - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100.4 mg/L
- Based on:
- test mat.
- Initial conc.:
- 101.5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 102.6 mg/L
- Based on:
- test mat.
- Initial conc.:
- 101.7 mg/L
- Based on:
- test mat.
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- BOD, mgO2/L adjusted to nominal concentrations
- Value:
- 32
- Sampling time:
- 2 d
- Remarks on result:
- other: Mean of two tests
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- BOD, mgO2/L adjusted to nominal concentrations
- Value:
- 63
- Sampling time:
- 7 d
- Remarks on result:
- other: Mean of two tests
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- BOD, mgO2/L adjusted to nominal concentrations
- Value:
- 80
- Sampling time:
- 12 d
- Remarks on result:
- other: Mean of two tests
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- BOD, mgO2/L adjusted to nominal concentrations
- Value:
- 83
- Sampling time:
- 14 d
- Remarks on result:
- other: Mean of two tests
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- BOD, mgO2/L adjusted to nominal concentrations
- Value:
- 86
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of two tests
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance underwent 86% biodegradation after 28 days in the test conditions. Biodegradation started on day 2 and reached 80% at the end of the 10-day window. The substance is therefore considered to be readily biodegradable under the conditions of the test.
- Executive summary:
The ready biodegradation potential of the test substance, Amyl salicylate, was determined using the OECD guideline 301F (Manometric respirometry test) over a test period of 28-days.
Amyl salicylate attained 86% biodegradation after 28-days under the conditions of the test. Biodegradation started on day 2 and reached 80% at the end of the 10 -day window. Thus, Amyl salicylate is considered to be readily biodegradable.
The substance was exposed to innoculum, prepared from predominantly domestic sewage, at nominal concentration of 100mg/L at approximately 22 degC.
A further similar test sample was used as a toxicity control, which attained greater than 80% degradation after 28-days, thus confirming the non-inhibitory effect of the test substance on the innoculum. A control sample of mineral medium, innoculum and aniline confirmed the actvity of the innoculum used.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions. A reference substance was not included in the study but the high level of degradation seen for the test item confirms that the inoculum was viable)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- Modified by using sealed test vessels to allow assessment of volatile substances.
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Amyl salicylate
- Molecular weight (if other than submission substance): 208.3
- Structural formula attached as image file (if other than submission substance): see Fig.
- Physical state: liquid
- Analytical purity: 100% nominal
- Lot/batch No.: R456
- Storage condition of test material: Store at room temperature in the dark.
- Other: Percentage Carbon = 69.1% - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- other: Organic carbon
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 27.2
- Sampling time:
- 4 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 66.9
- Sampling time:
- 14 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 81.3
- Sampling time:
- 28 d
- Conclusions:
- The substance is considered to be readily biodegradable after attaining 81.3% degradation within 28-days in a CO2 evolution ready biodegradation study and passing the 10 day window criterion.
- Executive summary:
The substance is considered to be readily biodegradable after attaining 81.3% degradation within 28-days in a CO2 evolution ready biodegradation study and passing the 10 -day window criterion.
Referenceopen allclose all
Reference material: Aniline (99.5% min.)
Toxicity control:
The toxicity of the test substance to the innoculum was checked by measuring the inhibitory rate on respiration compared to a control sample with test substance. The toxicity control and control contained the following:
Toxicity control: Mineral medium + test substance (100mg/L) + aniline (100mg/L, nominal) + innoculum
Control: Mineral medium + aniline (100mg/L, nominal) + innoculum.
Toxicity control attained 81% degradation after 28 -days, which demonstrates the non-inhibitory effect of the test substances on the inoculum used in the test.
Control: In the flasks containing aniline alone, pH remained roughly at the same level, which suggests that the final form of nitrogen is partly one of the acid forms NO2 - or NO3- and partlly the alkaline ion NH4 +. The ThOD corresponds to NO3- and was used for the calculation of the biodegradation rates of aniline. Using the ThOD corresponding to NH4+ would lead to higher degradation rates. In both cases, degradation of aniline exceeds 40% after 7 days and 65% after 14 days. The activity of the innoculum is thus verified and the test is considered as valid.
Description of key information
Readily biodegradable. The test substance exceeded the pass level of 60% within 28 days in two ready biodegradability tests. The 10-day window criterion was met in both studies.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The ready biodegradation potential of the test substance, Amyl salicylate, was determined using the OECD guideline 301F over a test period of 28-days (key study). Amyl salicylate attained 86% biodegradation after 28-days under the conditions of the test. Biodegradation started on day 2 and reached 80% at the end of the 10-day window. Thus, Amyl salicylate is considered to be readily biodegradable.
The substance was exposed to innoculum, prepared from predominantly domestic sewage, at nominal concentration of 100mg/L at approximately 22 degC. A further similar test sample was used as a toxicity control, which attained greater than 80% degradation after 28-days, thus confirming the non-inhibitory effect of the test substance on the innoculum.
In a supporting CO2 evolution ready biodegradation study, the substance attained 81.3% degradation within 28-days in a CO2 evolution ready biodegradation study. The 10 day window criterion was also met.
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