Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-483-3 | CAS number: 141-43-5
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
After feeding of the hydrochloric salt of the test substance, no disturbance of hepatic choline metabolism is noted even at very high dose levels of 1000 mg/kg bw.
Additional information
Hepatic choline status after treatment with the hydrochloric salt of the test substance was measured in a study performed by the Dow Chemical Company (2009). The samples were originating from the OECD 416 study in rats (ACC and Cefic, 2009). There was no indication of adverse hepatic effects after repeated feeding of the hydrochloric salt of the test substance even at high dose levels of 1000 mg/kg bw as expressed by liver weight of F0 and F1 parental animals of the 2 generation study in rats. In addition, no histopathological changes were noted, when liver sections from the control and high dose parental animals were compared. In addition no difference in hepatic choline levels and their respective metabolites from the analysed F1 parental females were measured. Thus it is concluded that after feeding of the hydrochloric salt of the test substance no disturbance of hepatic choline metabolism is noted even at very high dose levels of 1000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
