Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 472-170-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22/03/2006 - 29/08/2006
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 430 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER))
- Principles of method if other than guideline:
- The test material was applied to the epidermal surface of three skin discs for a contact period of 24 hours. At the end of the contact period the test material was removed using a jet of warm tap water. Corrosive substances produce an irreversible loss of normal stratum corneum integrity and function, this is measured as a reduction in the inherent TER. test materials that give a mean electrical resistance of 5 kOhm or less are considered likely to be corrosive in vivo. The TER was measured using a low voltage alternating current electronic databridge.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: B&K Universal Ltd Hull (UK)
- Age at study initiation: 21 - 23 d
- Acclimation period: 2 d
Test system
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 150µl - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 3 samples were used
- Number of animals:
- 1 animal (all samples were from the same animal)
- Details on study design:
- TEST SITE
- Area of exposure: 0.79 cm²
REMOVAL OF TEST SUBSTANCE
- Test material was scraped with a spatula
- Washing: with a jet of warm tap water
- Time after start of exposure: 24h
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: Transcutaneous Electrical Resistance (TER)
- Value:
- ca. 3.3
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 24 hours. Max. score: 6.2. Reversibility: no data. (migrated information)
Any other information on results incl. tables
Test Material Contact Period |
Tissue Number |
TER (kOhm) |
Mean TER (kOhm) |
Standard Deviation |
24 Hours |
1 |
6.2 |
3.3 |
+/- 2.5 |
2 |
2.1 |
|||
3 |
1.7 |
Positive Control Contact Period |
Tissue Number |
TER (kOhm) |
Mean TER (kOhm) |
Standard Deviation |
24 Hours |
4 |
0.939 |
0.830 |
+/- 0.16 |
5 |
0.651 |
|||
6 |
0.900 |
Negative Control Contact Period |
Tissue Number |
TER (kOhm) |
Mean TER (kOhm) |
Standard Deviation |
24 Hours |
7 |
17.4 |
17.9 |
+/- 5.32 |
8 |
23.5 |
|||
9 |
12.9 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Potential to cause corrosion Criteria used for interpretation of results: EU
- Conclusions:
- The mean TER recorded for the 24 hour test material contact period was less than 5 kOhm.
Following assessment of the data the test material is considered to have the potential to cause corrosion in vivo.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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