Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-215-7 | CAS number: 1313-99-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- other: K3/K4 studies
- Rationale for reliability incl. deficiencies:
- other: See Remarks
- Remarks:
- Though K3/K4 studies were evaluated and scored for reliability, robust summaries and unique IUCLID endpoint study records were not developed for such. Rather, a summary table of K3 and K4 studies evaluated and scored for this endpoint is provided in the field, “Any other information on results and table” for informational purposes.
Data source
Reference
- Reference Type:
- publication
- Title:
- Surface area- and mass-based comparison of fine and ultrafine nickel oxide lung toxicity and augmentation of allergic response in an ovalbumin asthma model
- Author:
- Roach KA, Anderson SE, Stefaniak AB, Shane HL, Kodali V, Kashon M, Roberts JR
- Year:
- 2 019
- Bibliographic source:
- Inhalation Toxicology 31(8):299-324
Materials and methods
Test material
- Reference substance name:
- Nickel oxide
- EC Number:
- 234-323-5
- EC Name:
- Nickel oxide
- Cas Number:
- 11099-02-8
- Molecular formula:
- NiO
- IUPAC Name:
- Nickel(II) oxide
Constituent 1
Results and discussion
Any other information on results incl. tables
Data Source |
Study Design and Findings | Reliability |
Roach et al. (2019). Surface area- and mass-based comparison of fine and ultrafine nickel oxide lung toxicity and augmentation of allergic response in an ovalbumin asthma model. Inhalation Toxicology; 31(8):299-324. | This study investigated the respiratory sensitisation of fine nickel oxide (181 nm) using the ovalbumin asthma model. Groups of mice were treated with nickel oxide via a single oropharyngeal aspiration at treatments of 0 (control) and 40 µg, followed by a sensitisation exposure to ovalbumin on days 1 and 10 and a challenge exposure on days 19 and 28. The lung function was assessed following the second challenge. Evidence of sensitisation to nickel oxide was observed on day 14 and 29 post-sensitisation through an increase in serum IgE levels. During histopathological analysis, inflammatory cell infiltration, macrophage accumulation and vacuolation was observed in the lungs of animals treated with nickel oxide. | K3: Does not meet important study design criteria. Only one nickel dose tested. |
Applicant's summary and conclusion
- Executive summary:
Studies were rated by an independent reviewer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.