Registration Dossier
Registration Dossier
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EC number: 282-013-3 | CAS number: 84082-68-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Myristica fragrans, Myristicaceae.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The result from the key study using WAFs was a 48h-EL50 = 15 mg/l.
The NOEL for growth rate was below a WAF prepared at a loading rate of 1 mg/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 15 mg/L
Additional information
In a key study the acute toxicity of Nutmeg oil towards with Pseudokirchneriella subcapitata was determined. Nutmeg Oil, Myristica fragrance oil reduced growth rate and inhibited the yield of this fresh water algae species significantly in a WAF prepared at a loading rate of 3.2 mg/l, corresponding to a measured carbon concentration of 0.7 mg/l.
The 48-h EL50 for growth rate reduction (ERL50: 0-48h) based on loading rates was 15 mg/l with a 95% confidence interval ranging from 6.4 to 35 mg/l.
The 48-h EL50 for yield inhibition (EYL50: 0-48h) based on loading rates was 5.3 mg/l with a 95% confidence interval ranging from 2.4 to 12 mg/l.
The 48-h NOEL for growth rate reduction equalled a WAF prepared at a loading rate of 1.0 mg/l. The NOEL for yield inhibition was below a WAF prepared at a loading rate of 0.32 mg/l.
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