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EC number: 212-344-0 | CAS number: 793-24-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Exposure to the substance during manufacure:
Over a period of 32 years data from one manufactoring site were collected and analyzed to determine the skin sensitizing potential of 6PPD. 70 workers were examined at regular intervals by the company medical department over the years. The results showed no evidence of a sensitation effects related to the skin exposure to 6PPD suggesting that the personal protective equipment worn during the process was adequate. The risk manangement measures taken at the site correspond to those described for the moderate hazard band.
Exposure to rubber fumes:
75 rubber fume exposure measurements at 9 different rubber manufacturing sites between 2004 and 2007 were performed. Exposures were mostly controlled to less than the UK Workplace Exposure Limit (WEL) of 0.6 mg/m3 (8 hour TWA). Only 6 from 75 exceeded this value. These exposures were measured on reactive site visits, in situations where a HSE inspector had reason to believe that exposure control was inadequate. No exposures in excess of the WEL were measured on the 2007 visits at sites selected at random in an attempt to capture the typical situation within the industry.
The median exposure from 9 sites visited between 2004 and 2007 was 0.13 mg/m3.In a more systematic assessement in the mid to late 1990s, the median exposure was 0.3 mg/m3.
The rubber fume WEL of 0.6 mg/m3 was exceeded at two sites. Six measured exposures, 8% of the measurements taken, exceeded the WEL. In conclusion of the measured data the WEL of 0.6 mg/m3 could therefore be taken as 90th percentile as a worst case. Almost all sites visited had significant deficiencies related to the engineering controls used to control rubber fume exposures. Moulding presses without local exhaust ventilation (LEV) fitted were frequently encountered. Where LEV was installed, deficiencies linked to design, use and maintenance were observed. The use of respiratory protective equipment (RPE) to control fume exposures was uncommon.
Additional information
Risk management measures described in Oberthür (2012), "Erfahrungsbericht über das Sensibilisierungspotential von N-(1 ,3-Dimethylbutyi)-N'-phenyl-p-phenylendiamin (6PPD; CAS: 793-24-8) ", Lanxess Deutschland GmbH, 2012 -10 -24.
EXPOSURE CONTROLS/PERSONAL PROTECTION:
- Protective gloves
- Protective glasses
- Protective helmet
- Protective shoes
- Protective clothing
REGULAR SAFETY INSTRUCTIONS CONCERNING PROTECTIVE CLOTHING, HANDLING AND STORAGE:
- Sectioning (black and white area) acc. to the German standard "GefStoffV"
- Instruction on avoiding skin contact
- Daily change of protective clothing
- Instructions on protective clothing (Dust suit and mask) while cleaning, maintenance and repair work
- Instructions on skin protection, skin cleansing and showering after work
TECHNICAL PRECAUTION:
- local exhaust ventilation at the filling station
- efficient exhaust ventilation in the working area
Details of rubber fume monitoring results according to Keen (2010), "A small survey of exposure to rubber process dust, rubber fume and N-nitrosamines", Health and Safety Executive publication, RR819 Research Report, Derbyshire, UK
Rubber fume exposures (mg/m3) measured by the Health and Safety Laboratory (HSE) between 2004 and 2007:
number of sites | number of measurements | exposure range | mean | geometric mean | median | results <LOD | results >WEL | sites >WEL | |
reactive visits | 4 | 45 | ND - 1.75 | 0.27 | 0.16 | 0.16 | 12 | 6 | 2 |
DRP survey | 5 | 30 | ND - 0.53 | 0.15 | 0.1 | 0.08 | 17 | 0 | 0 |
all data | 9 | 75 | ND - 1.75 | 0.22 | 0.14 | 0.13 | 29 | 6 | 2 |
The rubber fume WEL of 0.6 mg/m3 was exceeded at two sites. Six measured exposures, 8% of the measurements taken, exceeded the WEL. In conclusion of the measured data the WEL of 0.6 mg/m3 could therefore be taken as 90th percentile as a worst case. In general a concentration of 3% of the substance in rubber products is assumed and therefore the expected exposure (0.6 mg/m3) can be reduced using a default factor of 0.2. This results in an expected exposure for the substance of 0.12 mg/m3.
This latter mentioned result is in good agreement with exposure data estimated with the program ECETOC TRA where low dustiness was assumed for the uses applied during the production of tyres and GRG and retreating and recycling processes. In conclusion the assumption of low dustiness for the mentioned uses seems to be justifiable.
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