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Diss Factsheets
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EC number: 266-047-6 | CAS number: 65997-18-4 Frit is a mixture of inorganic chemical substances produced by rapidly quenching a molten, complex combination of materials, confining the chemical substances thus manufactured as nonmigratory components of glassy solid flakes or granules. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of frit. The primary members of this category are oxides of some or all of the elements listed below. Fluorides of these elements may also be included in combination with these primary substances.@Aluminum@Manganese@Antimony@Molybdenum@Arsenic@Neodymium@Barium@Nickel@Bismuth@Niobium@Boron@Phosphorus@Cadmium@Potassium@Calcium@Silicon@Cerium@Silver@Chromium@Sodium@Cobalt@Strontium@Copper@Tin@Gold@Titanium@Iron@Tungsten@Lanthanum@Vanadium@Lead@Zinc@Lithium@Zirconium@Magnesium
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 12th June - 19th June 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, available as an unpublished report with minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EN ISO 10993-11 tests for systemic toxicity
- Deviations:
- no
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Details on test material:
- dust containing nickel- FC911
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Test animals were 5 healthy Swiss mice weighing between 30-38g.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Five mice received an intraperitonel dose (1 ml/20g) of sample (0.2 g/ml). Another 5 mice received an intraperitoneal injection of the negative control solution (physiological saline). The mice were observed for 72 h for induced reactions and survival.
- Doses:
- intraperitonel dose (1 ml/20g) of sample (0.2 g/ml)
- No. of animals per sex per dose:
- % animals per dose, sex not reported
- Control animals:
- yes
- Details on study design:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: clinical observation
- Effect level:
- > 0.2 other: g/ml/20g bw
- Based on:
- test mat.
- Remarks on result:
- other: no effect
- Mortality:
- No mortality was observed.
- Clinical signs:
- No clinical signs were observed. Observations were made for hypokinesia, dyspnea, abdominal irritation, ptosis, dihorroea, prostration, cyanosis, tremors and death.
- Body weight:
- Not studied.
- Gross pathology:
- No gross pathology reported.
- Other findings:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- A 0.2 g/ml solution of test material FC911 was injected into 5 mice via the intraperitoneal route at a dose of 1 ml/20g body weight. This concentration had no effect on the animals when compared to the negative control animals which received an IP injection of physiological saline.
- Executive summary:
A 0.2 g/ml solution of test material FC911 (nickel containing dust). was injected into 5 mice via the intraperitoneal route at a dose of 1 ml/20g body weight. This concentration had no effect on the animals when compared to the negative control animals which received an IP injection of physiological saline. This study (Coronati, 2009) is considered reliable (2), it is a non-GLP, guideline study, available as an unpublished report with minor restrictions in design and/or reporting, but it is otherwise adequate for assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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