Propylidynetrimethanol, ethoxylated, esters with acrylic acid

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From February 13, 1984 to April 11, 1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

An acute dermal toxicity study was performed in rabbits. The test material was administered at a single dose level and observations were made for a period of 7d.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

ethoxylated trimethylolpropane triacrylate (TMPeoTA)

IUPAC Name:

ethoxylated trimethylolpropane triacrylate (TMPeoTA)

Constituent 2

Reference substance name:

Propylidynetrimethanol, ethoxylated, esters with acrylic acid

EC Number:

500-066-5

EC Name:

Propylidynetrimethanol, ethoxylated, esters with acrylic acid

Cas Number:

28961-43-5

Molecular formula:

n.a.

IUPAC Name:

Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-[(1-oxo-2- propenyl)oxy]-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1)

Details on test material:

- Substance type: Pure active substance
- Physical state: Very light amber liquid
- Analytical purity: 100 %
- Storage condition of test material: 15.55-29.44 °C
- Other: Density: 1.1 g/mL

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

IN-LIFE DATES: From: 1984-02-13 to: 1984-08-03

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 12000 mL/kg bw

Duration of exposure:

No data

Doses:

13200 mg/kg bw

No. of animals per sex per dose:

Four

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 d

Statistics:

No data

Results and discussion

Preliminary study:

Not applicable

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 13 200 mg/kg bw

Mortality:

None

Clinical signs:

other: Lack of food consumption was reported in one animal on days 5 and 6.

Gross pathology:

No data

Other findings:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

not classified

Conclusions:

The acute dermal LD50 of ethoxylated trimethylolpropane triacrylate (TMPeoTA) was determined to be >13,200 mg/kg bw in rabbits.

Executive summary:

A study was conducted to evaluate the acute dermal toxicity of ethoxylated trimethylolpropane triacrylate (TMPeoTA) in albino rabbits. A dermal application of 13,200 mg/kg TMPeoTA was applied to 4 rabbits. Parameters evaluated included mortality, clinical observations and body weight for a period of 7 days. No mortality was observed. Lack of food consumption was reported in one animal on days 5 and 6. In conclusion, the single dermal median lethal dose (LD50) of TMPeoTA was determined to be >13,200 mg/kg bw in rabbits.