Registration Dossier
Registration Dossier
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EC number: 218-216-0 | CAS number: 2082-79-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
absorprtion and effective excretion within 168hrs
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The distribution and excretion of C-labelled test substance was determined in the oral-gavage study in rats (CIBA-GEIGY, 1977). Four male rats were administered with 14C-test substance (specific gravity of 8.52 µCi/mg; radiochemical purity >99%) in a single oral-gavage dose of 10 mg/kg bw. The elimination of radioactivity and its retention was determined up to 168 h post administration. The distribution results showed highest residual radioactivity in the heart (0.54 µg/g). Slightly higher levels than blood (0.07 µg/g) showed thyroid, liver, kidney, brown/white fat and aorta (0.21-0.09 µg/g). In all other organs and tissues lower but still detectable levels were found. Within 0-48 hours after administration about 73% of the dose was eliminated from the body. Afterwards elimination proceeded slowly and was not fully completed at 168 hours. At that time 96% of the dose was recovered, 35% in the urine and 61% in the faeces.
In another study (GEIGY 1965), absorption of the C-labelled test substance was evaluated by the Levine technique in one rat. The substance was directly injected into the ligated gut lumen. After 3 hours, the ligated intestinal segment was removed and the amount of compound present was determined. The results showed 31.6 to 55.9 % absorption.
Combining all results, the test was well absorbed within 3 hours and almost fully (96%) eliminated with 168 hours.
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