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EC number: 272-180-0 | CAS number: 68783-04-0 A complex combination of hydrocarbons obtained as the extract from the re-extraction of solvent-refined heavy paraffinic distillate. It consists of saturated and aromatic hydrocarbons having carbon numbers predominantly in the range of C20 through C50.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to OECD Guideline 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 64742-65-0
- Cas Number:
- 64742-65-0
- IUPAC Name:
- 64742-65-0
- Reference substance name:
- solvent-dewaxed heavy paraffinic, sufficiently refined, IP 346 < 3%
- IUPAC Name:
- solvent-dewaxed heavy paraffinic, sufficiently refined, IP 346 < 3%
- Test material form:
- other: Oily liquid
- Details on test material:
- - Name of test material (as cited in study report): API 78-10 solvent dewaxed heavy paraffinic Oil
-CAS number: 64742-65-0
- Substance type: Other Lubricant base oil (sufficiently refined, IP 346 < 3%)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- the lubricant base oils were administered undiluted to either the abraded or unabraded skin of 2 male and 2 female New Zealand White rabbits (8 rabbits in total) at doses of either 2000 or 5000 mg/kg. The treated skin was occluded for 24 hours after which time the coverings were removed, and residual test material was wiped from the skin.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 or 5000 mg/kg
- No. of animals per sex per dose:
- 2/sex/dose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: see Other findings below
- Other findings:
- The only clinical signs were skin irritation and the occurrence of soft stool in some animals, but this latter effect was transient. Skin irritation ranged from slight to severe for erythema and oedema; slight to marked for atonia, desquamation, and fissuring; and from slight to moderate for coriaceousness.
Body weight:
Body weights were recorded prior to administration of test material and then 7 and 14 days post- administration
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 5000 mg/kg bw/day.
- Executive summary:
Justification for read across
Treated distillate aromatic extracts (TDAEs) are a further processing of untreated distillate aromatic extracts (UDAEs) in an attempt to reduce the amount of 3-7 ring PAC that is present. Since the treatment is mostly a selective reduction of PACs, the data from UDAEs can serve as read across where treatment was insufficient and a significant amount of PACs still remain (≥ 3 wt% DMSO extractables as measured by IP-346). Where treatment was sufficient to reduce the 3-7 ring PACs (<3 wt% DMSO extractables as measured by IP-346), the material is most similar to a lubricating base oil and it is this data that should be used for read across.
In an acute dermal toxicity study, groups of New Zealand white rabbits (2/male and 2/ female) were dermally exposed to lubricant base oil API 78 -10 for 24 hours at doses of 2000 or 5000 mg/kg bw. Animals then were observed for 14 days.
After 14 days all animals were killed and were subjected to a gross necropsy. There were no mortalities in any of the studies. The only clinical signs were skin irritation and the occurrence of soft stool in some animals, but this latter effect was transient. Skin irritation ranged from slight to severe for erythema and oedema; slight to marked for atonia, desquamation, and fissuring; and from slight to moderate for coriaceousness. The LD50s were greater than the doses that had been applied (i.e.2000 or 5000 mg/kg)
This study is classified as reliable without restriction because it was conducted according to OECD Guideline 402.
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