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Diss Factsheets
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EC number: 211-074-0 | CAS number: 629-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- BASF AG
- Bibliographic source:
- ECB IUCLID dataset
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- BASF AG
- Year:
- 2 000
- Bibliographic source:
- OECD SIDS
- Reference Type:
- secondary source
- Title:
- 1,6-Hexanediol
- Author:
- GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
- Year:
- 1 992
- Bibliographic source:
- BUA Report 107 (October 1992)
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hexane-1,6-diol
- EC Number:
- 211-074-0
- EC Name:
- Hexane-1,6-diol
- Cas Number:
- 629-11-8
- Molecular formula:
- C6H14O2
- IUPAC Name:
- hexane-1,6-diol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Hannover"
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- TEST MATERIAL
-Concentration: 10%, 20% - Doses:
- 800, 1600, 2000, 2500, 3200, 4600 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 300 mg/kg bw
- Mortality:
- 800 mg/kg bw: 1/5 within 7 days (killed by cohoused animals)
1600 mg/kg bw: 0/5
2000 mg/kg bw: 0/5
2500 mg/kg bw. 3/5 within 24 h; 4/5 within 7 days
3200 mg/kg bw: 5/5 within 24 h
6400 mg/kg bw: 5/5 within 24 h - Clinical signs:
- 800 mg/kg bw: staggering and slight hyperactivity
1600 mg/kg bw: hyperactivity; lateral position, accelerated respiration, atonia, after 4 h without symptomps
2000 mg/kg bw: staggering, atonia, lateral position, intermittent respiration, narcotic state, after 3 days without symptoms
2500 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration, 2 deaths within 4 h
3200 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration,3 deaths within 5 h, white-colored eyes after exitus
6400 mg/kg bw: intermittent respiration, lateral position or back posture, atonia, narcotic state, deaths within 1 - 4 h; white-colored eyes after exitus - Gross pathology:
- no abnormalities found
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.